Journal of Stroke & Cerebrovascular Diseases
Volume 15, Issue 1 , Pages 1-7, January 2006

Increased von Willebrand Factor in Acute Stroke Patients With Atrial Fibrillation

  • Mika Sato, MD

      Affiliations

    • Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan
    • Corresponding Author InformationAddress reprint requests to Mika Sato, MD, Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels—AKITA, 6-10 Senshu-Kubota-machi AKITA 010-0874 Japan.
    • ,
  • Akifumi Suzuki, MD

      Affiliations

    • Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan
    • ,
  • Ken Nagata, MD

      Affiliations

    • Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan
    • ,
  • Shinichiro Uchiyama, MD

      Affiliations

    • Department of Neurology, Neurological Institute, Tokyo Women’s Medical University, Tokyo, Japan.

Received 14 February 2005; received in revised form 27 July 2005; accepted 22 August 2005.

Plasma level of von Willebrand factor (vWF) is a useful marker not only for endothelial dysfunction, but also for left atrial thrombogenesis. We measured plasma levels of vWF antigen and other coagulation and fibrinolysis markers in 183 consecutive patients with acute ischemic stroke and compared these data between patients with and without atrial fibrillation (AF). vWF correlated with severity, outcome, and infarct size and were significantly higher in the AF group than in the non-AF group. The positive correlations of vWF with plasmin-α2 plasmin inhibitor complex and soluble fibrin monomer complex, and higher levels of vWF in patients with than without spontaneous echo contrast, indicate thrombogenesis in the left atrium. Plasma levels of vWF may reflect thrombogenesis in patients with AF.

Key Words:  von Willebrand factor , atrial fibrillation , acute ischemic stroke , hemostatic marker

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PII: S1052-3057(05)00126-6

doi:10.1016/j.jstrokecerebrovasdis.2005.09.005

Journal of Stroke & Cerebrovascular Diseases
Volume 15, Issue 1 , Pages 1-7, January 2006

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