The Number of Microbleeds on Gradient T2∗-weighted Magnetic Resonance Image at the Onset of Intracerebral Hemorrhage

Imaizumi, Toshio; Honma, Toshimi; Horita, Yoshifumi; Kawamura, Maiko; Kohama, Ikuhide; Miyata, Kei; Nyon, Kim Sang; Niwa, Jun

doi:10.1016/j.jstrokecerebrovasdis.2007.11.001

« Previous Next »Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 1 , Pages 30-34, January 2008

The Number of Microbleeds on Gradient T2^∗-weighted Magnetic Resonance Image at the Onset of Intracerebral Hemorrhage

Toshio Imaizumi, MD, PhD
- Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
- Address correspondence to Toshio Imaizumi, MD, PhD, Department of Neurosurgery, Kushiro City General Hospital, 1-12 Shunkodai, Kushiro, Hokkaido, Japan. 085-0822.
Toshimi Honma, MD, PhD
- Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
Yoshifumi Horita, MD
- Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
Maiko Kawamura, MD
- Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
Ikuhide Kohama, MD, PhD
- Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
Kei Miyata, MD
- Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
Kim Sang Nyon, MD, PhD
- Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
Jun Niwa, MD, PhD
- Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan

Received 11 April 2007; received in revised form 30 October 2007; accepted 14 November 2007.

Objective

Deep intracerebral hematoma (ICH) is frequently associated with microbleed (MB) arising from degenerated MB. Increased numbers of MB are correlated with increased age, and we examined a possible relationship between MB number and ICH onset in younger patients.

Methods

Excluding patients with ICH and a history of ICH, we examined the number of MB and other risk factors in 195 patients with deep ICH (97 male, 98 female) consecutively admitted to our hospital. The patients were equally divided into 3 subgroups according to age (groups A, B, and C). Odds ratios were estimated from logistic regression analyses.

Results

The number (percentage) of MB in group A (≤60 years old, n = 64) 5.0 ± 9.6 (65.6%) was less than group B (61-69 years old, n = 63) 6.6 ± 9.1 (79.4%) or group C (≥70 years old, n = 68) 6.0 ± 7.0 (86.8%). Multivariate analyses demonstrated that MB greater than or equal to 3 was significantly associated with higher age in group A versus B (odds ratio: 2.3; 95% confidence interval: 1.01-5.3; P = .046) and in group A versus C (odds ratio: 2.6; 95% confidence interval: 1.1-6.2; P =.030).