Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 4 , Pages 185-186, July 2007

Amphetamine-Associated Ischemic Stroke: Clinical Presentation and Proposed Pathogenesis

Singapore General Hospital, National Neuroscience Institute, Singapore.

Received 13 December 2006; received in revised form 31 March 2007; accepted 18 April 2007.

We report a young lady with acute left middle cerebral artery infarction after acute intake of amphetamine. This is the first case report of amphetamine-induced ischemic stroke with serial angiography and transcranial color-coded Doppler studies. The temporal sequence of stenosis of at least 3 weeks with subsequent complete resolution by 3 months and a “beaded” appearance on angiography support vasculitis or vasospasm as the pathogenesis of ischemic stroke in this patient. The presence of microembolic signals supports acute thrombosis at the site of vasculitis/vasospasm with distal embolism.

Key Words: Stroke, amphetamine, microembolic signals, transcranial color-coded Doppler

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PII: S1052-3057(07)00073-0

doi:10.1016/j.jstrokecerebrovasdis.2007.04.001

Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 4 , Pages 185-186, July 2007

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