Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 5 , Pages 199-202 , September 2007

Clopidogrel-Induced Platelet Inhibition Cannot Be Detected by the Platelet Function Analyzer-100 System in Stroke Patients

  • Nicole Kotzailias, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria
    • Corresponding Author InformationAddress reprint requests to Nicole Kotzailias, MD, Department of Neurology, Medical University Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria.
    • ,
  • Kirsten Elwischger, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria
    • ,
  • Thomas Sycha, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria
    • ,
  • Walter Rinner, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria
    • ,
  • Peter Quehenberger, MD

      Affiliations

    • Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Austria.
    • ,
  • Eduard Auff, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria
    • ,
  • Christian Müller, MD

      Affiliations

    • Department of Neurology, Medical University Vienna, Austria

Received 26 October 2006 ,Accepted 1 May 2007.

References 

  1. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high-risk patients. BMJ. 2002;324:71–86
  2. Antiplatelet Trialists’ Collaboration. Collaborative overview of randomised trials of antiplatelet therapy, I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ. 1994;308:81–106
  3. Grundmann K, Jaschonek K, Kleine B, et al. Aspirin non-responder status in patients with recurrent cerebral ischemic attacks. J Neurol. 2003;250:63–66
  4. Muller I, Besta F, Scholz C, et al. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost. 2003;89:783–787
  5. Crowe B, Abbas S, Meany B, et al. Detection of aspirin resistance by PFA-100: prevalence and aspirin compliance in patients with chronic stable angina. Semin Thromb Haemost. 2005;31:420–425
  6. Geiger J, Teichmann L, Grossmann R, et al. Monitoring of clopidogrel action: comparison of methods. Clin Chem. 2005;51:957–965
  7. Borzini P, Lazzaro A, Mazzucco L. Evaluation of the hemostatic function of stored platelet concentrates using the platelet function analyzer (PFA-100). Haematologica. 1999;84:1104–1109
  8. Homoncik M, Jilma B, Hergovich N, et al. Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100. Thromb Haemost. 2000;83:316–321
  9. Nitu-Whalley IC, Lee CA, Brown SA, et al. The role of the platelet function analyser (PFA-100™) in the characterization of patients with von Willebrand’s disease and its relationship with von Willebrand factor and the ABO blood group. Haemophilia. 2003;9:298–302
  10. Burn J, Dennis M, Bamford J, et al. Long-term risk of recurrent stroke after a first-ever stroke (The Oxfordshire Community Stroke Project). Stroke. 1994;25:333–337
  11. Grau AJ, Reiners S, Lichy C, et al. Platelet function under aspirin, clopidogrel and both after ischemic stroke: a cross-over study. Stroke. 2003;34:849–854
  12. Raman S, Jilma B. Time lag in platelet function inhibition by clopidogrel in stroke patients as measured by PFA-100. J Thromb and Haemost. 2004;2:2278–2279
  13. Bemardo A, Bergeron AL, Sun CW, et al. Von Willebrand factor present in fibrillar collagen anhances platelet adhesion to collagen and collagen-induced platelet aggregation. J Thromb Haemost. 2004;2:660–669
  14. Pidcock M, Harrison P. Can the PFA-100 be modified to detect P2Y12 inhibition?. J Thromb Haemost. 2006;4:1424–1426
  15. Budde U, Scharf RE, Franke P, et al. Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma. Blood. 1993;82:1749–1757
  16. Casonato A, Fabris F, Boscaro M, et al. Increased factor VIII/vWf levels in patients with reduced platelet number. Blut. 1987;54:281–288

 Supported by a research grant from the Medizinisch-Wissenschaftlicher Fonds des Buergermeisters der Bundeshauptstadt Wien (BGM project 2302).

PII: S1052-3057(07)00076-6

doi: 10.1016/j.jstrokecerebrovasdis.2007.05.001

Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 5 , Pages 199-202 , September 2007

Article Tools

* Image Usage & Resolution