Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 5 , Pages 220-224 , September 2007

Effect of Aspirin on Lipoprotein(a) in Patients With Ischemic Stroke

  • Gajender Singh Ranga, MD

      Affiliations

    • Department of Medicine, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi, India
    • Corresponding Author InformationAddress correspondence to Gajender Singh Ranga, C-32/Z-1, Second Floor (C-Block), Dilshad Garden, Delhi-110095, India.
    • ,
  • Om Prakash Kalra, MD, DM, MNAMS, FICP, FIACM

      Affiliations

    • Department of Medicine, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi, India
    • ,
  • Himanshu Tandon, MD

      Affiliations

    • Department of Medicine, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi, India
    • ,
  • Jasvinder Kaur Gambhir, PhD

      Affiliations

    • Department of Biochemistry, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi, India
    • ,
  • Gopesh Mehrotra, MD

      Affiliations

    • Department of Radiodiagnosis, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi, India.

Received 7 August 2006 ,Revised 26 March 2007 ,Accepted 8 May 2007.

References 

  1. Smith WS, Johnston SC, Easton JD. Cerebrovascular diseases. In:  Kasper DL,  Braunwald E,  Fauci AS, et al. editor. 16th ed.. New York: McGraw-Hill; 2005;p. 2372–2393
  2. Sloop GD. A critical analysis of the role of cholesterol in atherogenesis. Atherosclerosis. 1999;142:265–268
  3. Castelli WP, Garrison RJ, Wilson PW, et al. Incidence of coronary heart disease and lipoprotein cholesterol levels: The Framingham study. JAMA. 1986;256:2835–2838
  4. Gambhir JK, Kaur H, Gambhir DS, et al. Lipoprotein(a) as an independent risk factor for coronary artery disease in patients below 40 years of age. Indian Heart J. 2000;52:411–415
  5. Pedro-Botet J, Senti M, Nogues X, et al. Lipoprotein and apolipoprotein profile in men with ischemic stroke: Role of lipoprotein(a), triglyceride rich lipoproteins and apolipoprotein E polymorphism. Stroke. 1992;23:1556–1562
  6. Zenker G, Koltringer P, Bone G, et al. Lipoprotein(a) as a strong indicator for cerebrovascular disease. Stroke. 1986;17:942–945
  7. Schreiner PJ, Chambless LE, Brown SA, et al. Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: The ARIC study, atherosclerosis risk in communities. Ann Epidemiol. 1994;4:351–359
  8. Ridker PM, Stampfer MJ, Hennekens CH. Plasma concentration of lipoprotein(a) and the risk of future stroke. JAMA. 1995;273:1269–1273
  9. Markus HS, Kapadia R, Sherwood RA. Relationship between lipoprotein(a) and both stroke and carotid atheroma. Ann Clin Biochem. 1997;34:360–365
  10. Ohira T, Schreiner PJ, Morris JD, et al. Lipoprotein(a) and incident ischemic stroke: The atherosclerosis risk in communities (ARIC) study. Stroke. 2006;37:1407–1412
  11. Ridker PM, Libby P. Risk factors for atherothrombotic disease. In:  Zipes DP,  Libby P,  Bonow R, et al. editor. Braunwald’s heart disease, a text book of cardiology. Philadelphia: Elsevier Saunders; 2005;p. 935–958
  12. Akaike M, Azuma H, Kagawa A, et al. Effect of aspirin treatment on serum concentrations of lipoprotein(a) in patients with atherosclerotic diseases. Clin Chem. 2002;48:1454–1459
  13. Wolf PA, D’Agostino RB, Belanger AJ, et al. Probability of stroke: A risk profile from the Framingham study. Stroke. 1991;22:312–318
  14. Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and stroke: 13000 strokes in 450000 people in 45 prospective cohorts. Lancet. 1995;346:1647–1653
  15. Sharrett AR, Patsch W, Sorlie PD, et al. Association of lipoprotein, cholesterol, apolipoproteins A-1 and B, and triglycerides with carotid atherosclerosis and coronary heart disease: The atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb. 1994;14:1098–1104
  16. Nagayama M, Shinohara Y, Nagayama T. Lipoprotein(a) and ischemic cerebrovascular disease in young adults. Stroke. 1994;25:74–78
  17. Maeda S, Abe A, Seishima M, et al. Transient changes of serum lipoprotein(a) as an acute phase protein. Atherosclerosis. 1989;78:145–150
  18. Noma A, Abe A, Maeda S, et al. Lp(a): An acute-phase reactant?. Chem Phys Lipids. 1994;67/68:411–417
  19. Craig WY, Ledue TB. Lipoprotein(a) and the acute phase response. Clin Chim Acta. 1992;210:231–232
  20. Kargman DE, Tuck C, Berglund L, et al. Lipid and lipoprotein levels remain stable in acute ischemic stroke: The Northern Manhattan stroke study. Atherosclerosis. 1998;139:391–399
  21. Albucher JF, Ferrieres J, Ruidavets JB. Serum lipids in young patients with ischemic stroke: A case-control study. J Neurol Neurosurg Psychiatry. 2000;69:29–33
  22. Kagawa A, Azuma H, Akaike M, et al. Aspirin reduces apolipoprotein(a) [apo(a)] production in human hepatocytes by suppression of apo(a) gene transcription. J Biol Chem. 1999;274:34111–34115

PII: S1052-3057(07)00104-8

doi: 10.1016/j.jstrokecerebrovasdis.2007.05.003

Journal of Stroke & Cerebrovascular Diseases
Volume 16, Issue 5 , Pages 220-224 , September 2007

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