Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 1 , Pages 26-29 , January 2008

LOAD: A Pilot Study of the Safety of Loading of Aspirin and Clopidogrel in Acute Ischemic Stroke and Transient Ischemic Attack

  • Dawn M. Meyer, MSN, FNP

      Affiliations

    • Neurology Department, University of Texas Health Science Center at Houston, Texas
    • Corresponding Author InformationAddress correspondence to Dawn M. Meyer, MSN, FNP, Ortho/Neuro Services, Sharp Memorial Hospital, 7901 Frost St, San Diego, CA 92123.
    • ,
  • Karen C. Albright, DO, MPH

      Affiliations

    • Neurology Department, University of Texas Health Science Center at Houston, Texas
    • ,
  • Teresa A. Allison, PharmD, BCPS

      Affiliations

    • Memorial Hermann Hospital Houston, Texas
    • ,
  • James C. Grotta, MD

      Affiliations

    • Neurology Department, University of Texas Health Science Center at Houston, Texas

Received 1 August 2007 ,Revised 19 September 2007 ,Accepted 28 September 2007.

References 

  1. Barber PA, Zhang J, Demchuk A, et al. Why are stroke patients excluded from TPA therapy?. Neurology. 2001;56:1015
  2. Abciximab Emergent Stroke Treatment Trial I. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: Results of a randomized phase 2 trial. Stroke. 2005;36:880–890
  3. Mandava P, Lick SD, Rahman MA, et al. Initial safety experience of abciximab and heparin for acute ischemic stroke. Cerebrovasc Dis. 2005;19:276–278
  4. CAPRIE Steering Committee . A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet. 1996;348:1329
  5. The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial I. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502
  6. Diener H-C, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischemic stroke or transient ischemic attack in high-risk patients (MATCH): Randomized, double-blind, placebo-controlled trial. Lancet. 2004;364:331–337
  7. Hochholzer W, Trenk D, Frundi D, et al. Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation. 2005;111:2560–2564
  8. Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352:1179–1189
  9. Hankey GJ. Ongoing and planned trials of antiplatelet therapy in the acute and long-term management of patients with ischemic brain syndromes: Setting a new standard of care. Cerebrovasc Dis. 2004;17:11–16
  10. Kaste M, Hacke W, Fieschi C, et al. Results of the European cooperative acute stroke study (ECASS). Cerebrovasc Dis. 1995;5:225

PII: S1052-3057(07)00147-4

doi: 10.1016/j.jstrokecerebrovasdis.2007.09.006

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 1 , Pages 26-29 , January 2008

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