Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 1 , Pages 30-34 , January 2008

The Number of Microbleeds on Gradient T2∗-weighted Magnetic Resonance Image at the Onset of Intracerebral Hemorrhage

  • Toshio Imaizumi, MD, PhD

      Affiliations

    • Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
    • Corresponding Author InformationAddress correspondence to Toshio Imaizumi, MD, PhD, Department of Neurosurgery, Kushiro City General Hospital, 1-12 Shunkodai, Kushiro, Hokkaido, Japan. 085-0822.
    • ,
  • Toshimi Honma, MD, PhD

      Affiliations

    • Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
    • ,
  • Yoshifumi Horita, MD

      Affiliations

    • Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
    • ,
  • Maiko Kawamura, MD

      Affiliations

    • Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
    • ,
  • Ikuhide Kohama, MD, PhD

      Affiliations

    • Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
    • ,
  • Kei Miyata, MD

      Affiliations

    • Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
    • ,
  • Kim Sang Nyon, MD, PhD

      Affiliations

    • Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan
    • ,
  • Jun Niwa, MD, PhD

      Affiliations

    • Department of Neurosurgery at Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan

Received 11 April 2007 ,Revised 30 October 2007 ,Accepted 14 November 2007.

References 

  1. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2∗-weighted MR images in patients with spontaneous intracerebral hemorrhage: Evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20:637–642
  2. Atlas SW, Thulborn KR. MR detection of hyperacute parenchymal hemorrhage of the brain. AJNR Am J Neuroradiol. 1998;19:1471–1507
  3. Wardlaw JM, Statham PFX. How often is hemosiderin not visible on routine MR image following traumatic intracerebral hemorrhage?. Neuroradiology. 2000;42:81–84
  4. Imaizumi T, Horita Y, Chiba M, et al. Dot-like hemosiderin spots on gradient echo T2∗-weighted magnetic resonance imaging are associated with past history of small vessel disease in patients with intracerebral hemorrhage. J Neuroimaging. 2004;14:251–257
  5. Imaizumi T, Horita Y, Hashimoto Y, et al. Dot-like hemosiderin spots on T2∗-weighted MRI as a predictor of stroke recurrence: A prospective study. J Neurosurg. 2004;101:915–920
  6. Imaizumi T, Honma T, Horita Y, et al. Dotlike hemosiderin spots are associated with past hemorrhagic strokes in patients with lacunar infarction. J Neuroimaging. 2005;15:157–163
  7. Good CD, Ng VW, Clifton A, et al. Amyloid angiopathy causing widespread miliary hemorrhage within the brain evident on MRI. Neuroradiology. 1998;40:308–311
  8. Tanaka A, Ueno Y, Nakayama Y, et al. Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke. 1999;30:1637–1642
  9. Kwa VIH, Franke CL, Verbeeten B, et al. Silent intracerebral microhemorrhage in patients with ischemic stroke. Ann Neurol. 1998;44:372–377
  10. Horita Y, Imaizumi T, Niwa J, et al. Analysis of dot-like hemosiderin spots using brain dock system. [in Japanese] No Shinkei Geka. 2003;31:263–267
  11. Lee S-H, Bae H-J, Yoon B-W, et al. Low concentration of serum total cholesterol is associated with multifocal signal loss lesion on gradient-echo magnetic resonance imaging: Analysis of risk factors for multifocal signal loss lesions. Stroke. 2002;33:2845–2849
  12. Ariesen MJ, Claus SP, Rinkel GJE, et al. Risk factor for intracerebral hemorrhage in the general population: A systemic review. Stroke. 2003;34:2060–2066
  13. Imaizumi T, Chiba M, Honma T, et al. Dynamics of dot-like hemosiderin spots associated with intracerebral hemorrhage. J Neuroimaging. 2003;13:155–157
  14. National Diabetes Data Group. Report of the expert committee on the diagnostic classification of diabetes. Diabetes Care. 1997;20:1183–1197
  15. Jerrard-Dunne P, Cloud G, Hassan A, et al. Evaluating the genetic component of ischemic stroke subtypes: A familial history study. Stroke. 2003;34:1364–1369
  16. Dichgans M, Holtmannspotter M, Herzog J, et al. Cerebral microbleeds in CADASIL: A gradient-echo magnetic resonance imaging and autopsy study. Stroke. 2002;33:67–71
  17. Feldmann E, Broderick JP, Kerman WN, et al. Major risk factors for intracerebral hemorrhage in the young are modifiable. Stroke. 2005;36:1881–1885

PII: S1052-3057(07)00172-3

doi: 10.1016/j.jstrokecerebrovasdis.2007.11.001

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 1 , Pages 30-34 , January 2008

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