Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 141-146 , May 2008

The Effect of Physiologic Derangement in Patients with Stroke Treated with Thrombolysis

  • Titto T. Idicula, MD

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway
    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • Corresponding Author InformationAddress correspondence to Titto T. Idicula, MD, Department of Neurology, Haukeland University Hospital, N-5021 Bergen, Norway.
    • ,
  • Ulrike Waje-Andreassen, MD

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway
    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • ,
  • Jan Brogger, MD, PhD

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway
    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • ,
  • Halvor Naess, MD, PhD

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Maria Therese Lundstadsveen

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Lars Thomassen, MD, PhD

      Affiliations

    • Department of Neurology, Haukeland University Hospital, Bergen, Norway

Received 14 November 2007 ,Revised 19 December 2007 ,Accepted 8 January 2008.

References 

  1. Kammersgaard LP, Jorgensen HS, Rungby JA, et al. Admission body temperature predicts long-term mortality after acute stroke: The Copenhagen stroke study. Stroke. 2002;33:1759–1762
  2. Jorgensen H, Nakayama H, Raaschou HO, et al. Stroke in patients with diabetes: The Copenhagen stroke study. Stroke. 1994;25:1977–1984
  3. Leira R, Rodriguez-Yanez M, Castellanos M, et al. Hyperthermia is a surrogate marker of inflammation-mediated cause of brain damage in acute ischemic stroke. J Intern Med. 2006;260:343–349
  4. Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: A systematic overview. Stroke. 2001;32:2426–2432
  5. Suzuki T, Bramlett HM, Ruenes G, et al. The effects of early post-traumatic hyperthermia in female and ovariectomized rats. J Neurotrauma. 2004;21:842–853
  6. Meden P, Overgaard K, Pedersen H, et al. The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model. Brain Res. 1994;647:131–138
  7. Deng H, Han HS, Cheng D, et al. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke. 2003;34:2495–2501
  8. Azzimondi G, Bassein L, Nonino F, et al. Fever in acute stroke worsens prognosis: A prospective study. Stroke. 1995;26:2040–2043
  9. Reith J, Jorgensen HS, Pedersen PM, et al. Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome. Lancet. 1996;347:422–425
  10. Castillo J, Davalos A, Marrugat J, et al. Timing for fever-related brain damage in acute ischemic stroke. Stroke. 1998;29:2455–2460
  11. Hajat C, Hajat S, Sharma P. Effects of poststroke pyrexia on stroke outcome: A meta-analysis of studies in patients. Stroke. 2000;31:410–414
  12. Williams LS, Rotich J, Qi R, et al. Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke. Neurology. 2002;59:67–71
  13. Baird TA, Parsons MW, Phanh T, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke. 2003;34:2208–2214
  14. Wang Y, Lim LL, Levi C, et al. Influence of admission body temperature on stroke mortality. Stroke. 2000;31:404–409
  15. varez-Sabin J, Molina CA, Ribo M, et al. Impact of admission hyperglycemia on stroke outcome after thrombolysis: Risk stratification in relation to time to reperfusion. Stroke. 2004;35:2493–2498
  16. Leigh R, Zaidat OO, Suri MF, et al. Predictors of hyperacute clinical worsening in ischemic stroke patients receiving thrombolytic therapy. Stroke. 2004;35:1903–1907
  17. Adams HP, del ZG, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38:1655–1711
  18. Spengos K, Tsivgoulis G, Zakopoulos N. Blood pressure management in acute stroke: A long-standing debate. Eur Neurol. 2006;55:123–135
  19. Brott T, Lu M, Kothari R, et al. Hypertension and its treatment in the NINDS rt-PA stroke trial. Stroke. 1998;29:1504–1509
  20. Phillips SJ. Pathophysiology and management of hypertension in acute ischemic stroke. Hypertension. 1994;23:131–136
  21. Castillo J, Leira R, Garcia MM, et al. Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome. Stroke. 2004;35:520–526
  22. Chamorro A, Vila N, Ascaso C, et al. Blood pressure and functional recovery in acute ischemic stroke. Stroke. 1998;29:1850–1853
  23. Kwiatkowski TG, Libman RB, Frankel M, et al. Effects of tissue plasminogen activator for acute ischemic stroke at one year: National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator stroke study group. N Engl J Med. 1999;340:1781–1787
  24. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: Definitions for use in a multicenter clinical trial; TOAST, trial of Org 10172 in acute stroke treatment. Stroke. 1993;24:35–41
  25. Boysen G, Christensen H. Stroke severity determines body temperature in acute stroke. Stroke. 2001;32:413–417
  26. Ernon L, Schrooten M, Thijs V. Body temperature and outcome after stroke thrombolysis. Acta Neurol Scand. 2006;114:23–28
  27. Yenari MA, Palmer JT, Bracci PM, et al. Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent. Thromb Res. 1995;77:475–481
  28. Schwarzenberg H, Muller-Hulsbeck S, Brossman J, et al. Hyperthermic fibrinolysis with rt-PA: In vitro results. Cardiovasc Intervent Radiol. 1998;21:142–145
  29. Nagi M, Pfefferkorn T, Haberl RL. Blood glucose and stroke. [in German] Nervenarzt. 1999;70:944–949
  30. Brown AM, Tekkok SB, Ransom BR. Glycogen regulation and functional role in mouse white matter. J Physiol. 2003;549:501–512
  31. Ribo M, Molina C, Montaner J, et al. Acute hyperglycemia state is associated with lower tPA-induced recanalization rates in stroke patients. Stroke. 2005;36:1705–1709
  32. Lin B, Ginsberg MD, Busto R. Hyperglycemic exacerbation of neuronal damage following forebrain ischemia: Microglial, astrocytic and endothelial alterations. Acta Neuropathol (Berl). 1998;96:610–620
  33. Yamamoto Y, Akiguchi I, Oiwa K, et al. Adverse effect of nighttime blood pressure on the outcome of lacunar infarct patients. Stroke. 1998;29:570–576
  34. Ahmed N, Wahlgren G. High initial blood pressure after acute stroke is associated with poor functional outcome. J Intern Med. 2001;249:467–473
  35. Carlberg B, Asplund K, Hagg E. The prognostic value of admission blood pressure in patients with acute stroke. Stroke. 1993;24:1372–1375
  36. Aslanyan S, Fazekas F, Weir CJ, et al. Effect of blood pressure during the acute period of ischemic stroke on stroke outcome: A tertiary analysis of the GAIN international trial. Stroke. 2003;34:2420–2425
  37. Generalized efficacy of t-PA for acute stroke: Subgroup analysis of the NINDS t-PA stroke trial. Stroke. 1997;28:2119–2125

 Supported by the Frank Mohn Foundation and Nasjonalforeningen for Folkehelse.

PII: S1052-3057(08)00014-1

doi: 10.1016/j.jstrokecerebrovasdis.2008.01.010

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 141-146 , May 2008

Article Tools

* Image Usage & Resolution