Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 147-152 , May 2008

Association of Serum Bilirubin with Ischemic Stroke Outcomes

  • Sandra Pineda, BS

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Oh Young Bang, MD, PhD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • Department of Emergency Medicine, University of California at Los Angeles Medical Center
    • ,
  • Jeffrey L. Saver, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Sidney Starkman, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • Department of Neurology and Stroke Center, Samsung Medical Center, Sungkyunkwan University, South Korea
    • ,
  • Susan W. Yun, BS

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • David S. Liebeskind, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Doojin Kim, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Latisha K. Ali, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Samir H. Shah, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • ,
  • Bruce Ovbiagele, MD

      Affiliations

    • Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center
    • Corresponding Author InformationAddress correspondence to Bruce Ovbiagele, MD, Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095.

Received 16 November 2007 ,Revised 20 December 2007 ,Accepted 8 January 2008.

References 

  1. Stocker R, Yamamoto Y, McDonagh AF, et al. Bilirubin is an antioxidant of possible physiological importance. Science. 1987;235:1043–1046
  2. Dore S, Takahashi M, Ferris CD, et al. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A. 1999;96:2445–2450
  3. Dohi K, Mochizuki Y, Satoh K, et al. Transient elevation of serum bilirubin (a heme oxygenase-1 metabolite) level in hemorrhagic stroke: Bilirubin is a marker of oxidant stress. Acta Neurochir Suppl. 2003;86:247–249
  4. Schretlen DJ, Inscore AB, Vannorsdall TD, et al. Serum uric acid and brain ischemia in normal elderly adults. Neurology. 2007;69:1418–1423
  5. Karagiannis A, Mikhailidis DP, Tziomalos K, et al. Serum uric acid as an independent predictor of early death after acute stroke. Circ J. 2007;71:1120–1127
  6. Amaro S, Soy D, Obach V, Cervera A, et al. A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke. Stroke. 2007;38:2173–2175
  7. Ovbiagele B, Kidwell CS, Starkman S, et al. Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003;3:9–20
  8. Herishanu Y, Abramsky O, Lavy S. Hyperbilirubinemia in acute ischemic stroke. J Neurol Sci. 1971;14:417–420
  9. Hatano S. Experience from a multicenter stroke register: A preliminary report. Bull World Health Organ. 1976;54:541–553
  10. Brott T, Adams HP, Olinger CP, et al. Measurements of acute cerebral infarction: A clinical examination scale. Stroke. 1989;20:864–870
  11. Lee L, Kidwell CS, Alger J, et al. Impact on stroke subtype diagnosis of early diffusion-weighted magnetic resonance imaging and magnetic resonance angiography. Stroke. 2000;31:1081–1089
  12. Frankel MR, Morgenstern LB, Kwiatkowski T, et al. Predicting prognosis after stroke: A placebo group analysis from the national institute of neurological disorders and stroke rt-pa stroke trial. Neurology. 2000;55:952–959
  13. Dulli DA, Stanko H, Levine RL. Atrial fibrillation is associated with severe acute ischemic stroke. Neuroepidemiology. 2003;22:118–123
  14. Bruno A, Biller J, Adams HP, et al. Acute blood glucose level and outcome from ischemic stroke: Trial of org 10172 in acute stroke treatment (toast) investigators. Neurology. 1999;52:280–284
  15. Wilterdink J, Bendixen B, Adams HP, et al. Effect of prior aspirin use on stroke severity in the trial of org 10172 in acute stroke treatment (toast). Stroke. 2001;32:2836–2840
  16. Greisenegger S, Mullner M, Tentschert S, et al. Effect of pretreatment with statins on the severity of acute ischemic cerebrovascular events. J Neurol Sci. 2004;221:5–10
  17. Ovbiagele B, Weir CJ, Saver JL, et al. Effect of smoking status on outcome after acute ischemic stroke. Cerebrovasc Dis. 2006;21:260–265
  18. Hidalgo FJ, Zamora R, Dillard CJ, et al. Can serum bilirubin be an index of in vivo oxidative stress?. Med Hypotheses. 1990;33:207–211
  19. Mamtani M, Patel A, Renge R, et al. Prognostic value of direct bilirubin in neonatal hyperbilirubinemia. Indian J Pediatr. 2007;74:819–822
  20. Shiomi S, Habu D, Kuroki T, et al. Clinical usefulness of conjugated bilirubin levels in patients with acute liver diseases. J Gastroenterol. 1999;34:88–93
  21. Reinhartz O, Farrar DJ, Hershon JH, et al. Importance of preoperative liver function as a predictor of survival in patients supported with thoratec ventricular assist devices as a bridge to transplantation. J Thorac Cardiovasc Surg. 1998;116:633–640
  22. Li B, Wang Z, Fang JJ, et al. Evaluation of prognostic markers in severe drug-induced liver disease. World J Gastroenterol. 2007;13:628–632

PII: S1052-3057(08)00015-3

doi: 10.1016/j.jstrokecerebrovasdis.2008.01.009

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 147-152 , May 2008

Article Tools