Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 153-155 , May 2008

Efficiency of Citicoline in Increasing Muscular Strength of Patients with Nontraumatic Cerebral Hemorrhage: A Double-blind Randomized Clinical Trial

Received 4 December 2007 ,Revised 30 December 2007 ,Accepted 8 January 2008.

References 

  1. Krupinski J, Slevin M, Badimon L. Citicoline inhibits MAP kinase signaling pathways after focal cerebral ischemia. Neurochem Res. 2005;30:1067–1073
  2. Alexandrov AV. Citicoline Ferrer Internacional. J Neurosci Res. 2002;70:133–139
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: A review of the literature. Altern Med Rev. 2004;9:17–31
  4. Secades JJ, Frontera G. CDP-choline. Pharmacol Clin Rev. 1995;17:1–54(suppl)
  5. Warach S, Pettigrew LC, Dashe JF, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging: Citicoline 010 investigators. Ann Neurol. 2000;48:713–722
  6. Schäbitz WR, Li F, Irie K, et al. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke. 1999;30:427–431discussion 431–432
  7. Clark W, Gunion-Rinker L, Lessov N, et al. Citicoline treatment for experimental intracerebral hemorrhage in mice. Stroke. 1998;29:2136–2140
  8. Secades JJ, Alvarez-Sabín J, Rubio F, et al. Trial Investigators. Citicoline in intracerebral hemorrhage: A double-blind, randomized, placebo-controlled, multi-center pilot study. Cerebrovasc Dis. 2006;21:380–385
  9. Bickley LS, Szilagyi PG, Bates B. Bates' guide to physical examination and history taking. 9th ed.. Philadelphia: Lippincott Williams and Wilkins; 2007;
  10. Dávalos A, Castillo J, Alvarez-Sabín J, et al. Oral citicoline in acute ischemic stroke: An individual patient data pooling analysis of clinical trials. Stroke. 2002;33:2850–2857
  11. Sobrado M, López MG, Carceller F, et al. Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia. Neuroscience. 2003;118:107–113
  12. Alonso de Leciñana M, Gutiérrez M, Roda JM, et al. Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke. J Neurol Sci. 2006;247:119–120
  13. Clark WM, Wechsler LR, Sabounjian LA, et al. Citicoline Stroke Study Group. A phase III randomized efficacy trial of 2000mg citicoline in acute ischemic stroke patients. Neurology. 2001;57:1595–1602
  14. Clark WM, Williams BJ, Selzer KA, et al. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke. 1999;30:2592–2597
  15. Yu W, Shen F, Ma Z. Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20:94–96
  16. Yamamoto M, Shimizu M, Kawabata S, et al. Effects of YM-14673, a new TRH analogue, on neurological deficits in rats with experimental cerebral hematoma. Arch Int Pharmacodyn Ther. 1989;299:55–64
  17. Adibhatla RM, Hatcher JF. Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia. J Neurosci Res. 2003;73:308–315
  18. Adibhatla RM, Hatcher JF. Citicoline mechanisms and clinical efficacy in cerebral ischemia. J Neurosci Res. 2002;70:133–139
  19. Zweifler RM. Membrane stabilizer: Citicoline. Curr Med Res Opin. 2002;18:s14–s17(suppl)
  20. Adibhatla RM, Hatcher JF, Dempsey RJ. Citicoline: Neuroprotective mechanisms in cerebral ischemia. J Neurochem. 2002;80:12–23
  21. Ovbiagele B, Kidwell CS, Starkman S, et al. Potential role of neuroprotective agents in the treatment of patients with acute ischemic stroke. Curr Treat Options Cardiovasc Med. 2003;5:441–449
  22. Adibhatla RM, Hatcher JF, Larsen EC, et al. CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: Phosphocholine cytidylyltransferase after stroke. J Biol Chem. 2006;281:6718–6725
  23. D'Orlando KJ, Sandage BW. Citicoline (CDP-choline): Mechanisms of action and effects in ischemic brain injury. Neurol Res. 1995;17:281–284

PII: S1052-3057(08)00018-9

doi: 10.1016/j.jstrokecerebrovasdis.2008.01.006

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 3 , Pages 153-155 , May 2008

Article Tools