Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 4 , Pages 212-217, July 2008

Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

  • Aaron McMurtray, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
    • Corresponding Author InformationAddress correspondence to Aaron McMurtray, MD, Hawaii AIDS Clinical Research Program (HACRP), The University of Hawaii, Leahi Hospital, Young Bldg, 5th Floor, 3675 Kilauea Ave, Honolulu, HI, 96816.
    • ,
  • Beau Nakamoto, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
    • Neurology Department, Straub Clinic and Hospital, Honolulu, HI
    • ,
  • Cecelia Shikuma, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
    • ,
  • Victor Valcour, MD

      Affiliations

    • Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

Received 10 January 2008; received in revised form 24 February 2008; accepted 25 February 2008.

Background

As many human immunodeficiency virus (HIV)-seropositive individuals are now living longer after infection because of highly active antiretroviral therapy, aging-related manifestations of cerebral small-vessel ischemic vascular disease, such as brain white matter hyperintensities (WMHs), are becoming increasingly important in this population.

Goals

This study was designed to determine the relationship between WMHs and cortical volumes in HIV-seropositive individuals.

Materials and Methods

Voxel-based morphometry was used to compare cortical volumes among 62 HIV-seropositive individuals participating in the Hawaii Aging with HIV Cohort Study, 30 with moderate WMHs and 32 with minimal or no WMHs.

Results

Presence of moderate WMHs was associated with decreased cortical volumes in the frontal lobes bilaterally.

Conclusion

These findings suggest that age-related WMHs are associated with reduced frontal gray matter volumes in HIV-seropositive individuals, supporting the hypothesis that the frontal lobes may have greater susceptibility to the effects of small-vessel ischemic vascular disease.

Key Words: Leukoaraiosis, ischemic vascular disease, aging, human immunodeficiency virus infection

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 Supported by the PhD in Clinical Research Program at the University of Hawaii, 1K07GM072A84. Additional support from National Institute of Neurological Disorders and Stroke (NINDS) grant 1U54NS43049, National Center for Research Resources (NCRR) grant P20 RR11091, and Research Centers in Minority Institutions (RCMI) grant G12 RR/AI 03061.

PII: S1052-3057(08)00066-9

doi:10.1016/j.jstrokecerebrovasdis.2008.02.005

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 4 , Pages 212-217, July 2008

Article Tools

* Image Usage & Resolution