Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 4 , Pages 212-217 , July 2008

Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

  • Aaron McMurtray, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
    • Corresponding Author InformationAddress correspondence to Aaron McMurtray, MD, Hawaii AIDS Clinical Research Program (HACRP), The University of Hawaii, Leahi Hospital, Young Bldg, 5th Floor, 3675 Kilauea Ave, Honolulu, HI, 96816.
  • ,
  • Beau Nakamoto, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
    • Neurology Department, Straub Clinic and Hospital, Honolulu, HI
  • ,
  • Cecelia Shikuma, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
  • ,
  • Victor Valcour, MD

      Affiliations

    • Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

Received 10 January 2008 ,Revised 24 February 2008 ,Accepted 25 February 2008.

References 

  1. Goodkin K, Wilkie FL, Concha M, et al. Aging and neuro-AIDS conditions and the changing spectrum of HIV-1 associated morbidity and mortality. J Clin Epidemiol. 2001;54:S35–S43(suppl)
  2. Inzitari D. Leukoaraiosis: An independent risk factor for stroke?. Stroke. 2003;34:2067–2071
  3. Basile AM, Pantoni L, Pracucci G, et al. Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes: The LADIS (leukoaraiosis and disability in the elderly) study. Cerebrovasc Dis. 2006;21:315–322
  4. Ovbiagele B, Saver JL. Cerebral white matter hyperintensities on MRI: Current concepts and therapeutic implications. Cerebrovasc Dis. 2006;22:83–90
  5. Rossi R, Boccardi M, Sabattoli F, et al. Topographic correspondence between white matter hyperintensities and brain atrophy. J Neurol. 2006;253:919–927
  6. DeCarli C, Murphy DG, Tranh M, et al. The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology. 1995;45:2077–2084
  7. Mirsen TR, Lee DH, Wong CJ, et al. Clinical correlates of white matter changes on magnetic resonance imaging scans of the brain. Arch Neurol. 1991;48:1015–1021
  8. Ylikoski A, Erkinjuntti T, Raininko R, et al. White matter hyperintensities on MRI in the neurologically nondiseased elderly. Stroke. 1995;26:1171–1177
  9. Boone KB, Miller BL, Lesser IM, et al. Neuropsychological correlates of white-matter lesions in healthy elderly subjects: A threshold effect. Arch Neurol. 1992;49:549–554
  10. Mendez MF, Cummings JL. Dementia: A clinical approach. 3rd edition. Philadelphia: Elsevier Science Publishing Company; 2003;
  11. Longstreth WT, Bernick C, Manolio TA, et al. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: The cardiovascular health study. Arch Neurol. 1998;55:1217–1225
  12. Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Rotterdam scan study: Incidence and risk factors of silent brain infarcts in the population-based Rotterdam scan study. Stroke. 2003;34:392–396
  13. Capizzano AA, Acion L, Bekinschtein T, et al. White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2004;75:822–827
  14. Valcour V, Shikuma C, Shiramizu B, et al. Higher frequency of dementia in older HIV+ individuals: The Hawaii aging with HIV cohort. Neurology. 2004;63:822–827
  15. McMurtray AM, Nakamoto B, Shikuma C, et al. Small vessel vascular disease in HIV infection: The Hawaii aging with HIV cohort study. Cerebrovasc Dis. 2007;24:236–241
  16. de Leeuw F-E, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study, the Rotterdam scan study. J Neurol Neurosurg Psychiatry. 2001;70:9–14
  17. Members and Collaborators of the Wellcome Department of Imaging Neuroscience. “Statistical Parametric Mapping.” Available from: URL:www.fil.ion.ucl.ac.uk/spm. Last accessed April 14, 2008.
  18. Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage. 2001;14:21–36
  19. Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol. 1987;44:21–23
  20. Roman GC, Erkinjuntti T, Wallin A, et al. Subcortical ischemic vascular dementia. Lancet Neurol. 2002;1:426–436
  21. Chui HC, Victoroff JI, Margolin D, et al. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's disease diagnostic and treatment centers. Neurology. 1992;42:473–480
  22. Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: Diagnostic criteria for research studies; report of the NINDS-AIREN international workshop. Neurology. 1993;43:250–260
  23. Hachinski VC, Lassen NA, Marshall J. Multi-infarct dementia: A cause of mental deterioration in the elderly. Lancet. 1974;2:207–210
  24. The World Health Organization. International statistical classification of diseases and related health problems, 1989 rev. Geneva: World Health Organization; 1992;311-388
  25. Sultzer DL, Mahler ME, Cummings JL, et al. Cortical abnormalities associated with subcortical lesions in vascular dementia: Clinical and positron emission tomographic findings. Arch Neurol. 1995;52:773–780
  26. Takahashi W, Takagi S, Ide M, et al. Reduced cerebral glucose metabolism in subjects with incidental hyperintensities on magnetic resonance imaging. J Neurol Sci. 2000;176:21–27
  27. Wen W, Sachdev P, Shnier R, et al. Effect of white matter hyperintensities on cortical cerebral blood volume using perfusion MRI. NeuroImage. 2004;21:1350–1356
  28. Fazekas F, Schmidt R, Kleinert R, et al. The spectrum of age-associated brain abnormalities: Their measurement and histopathological correlates. J Neural Transm Suppl. 1998;53:31–39
  29. Ozdener H. Molecular mechanisms of HIV-1 associated neurodegeneration. J Biosci. 2005;30:391–405
  30. Tullberg M, Fletcher E, DeCarli C, et al. White matter lesions impair frontal lobe function regardless of their location. Neurology. 2004;63:246–253
  31. De Groot JC, De Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and cognitive function: The Rotterdam scan study. Ann Neurol. 2000;47:145–151
  32. Longstreth WT, Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: The cardiovascular health study. Stroke. 1996;27:1274–1282
  33. De Groot JC, De Leeuw FE, Oudkerk M, et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol. 2002;52:335–341
  34. Harrison MJ, Newman SP, Hall-Craggs MA, et al. Evidence of CNS impairment in HIV infection: Clinical, neuropsychological, EEG, and MRI/MRS study. J Neurol Neurosurg Psychiatry. 1998;65:301–307
  35. Aylward EH, Brettschneider PD, McArthur JC, et al. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry. 1995;152:987–994
  36. McArthur JC, Kumar AJ, Johnson DW, et al. Incidental white matter hyperintensities on magnetic resonance imaging in HIV-1 infection. J Acquir Immune Defic Syndr. 1990;3:252–259
  37. Levin HS, Williams DH, Borucki MJ, et al. Magnetic resonance imaging and neuropsychological findings in human immunodeficiency virus infection. J Acquir Immune Defic Syndr. 1990;3:757–762
  38. Dooneief G, Bello J, Todak G, et al. A prospective controlled study of magnetic resonance imaging of the brain in gay men and parenteral drug users with human immunodeficiency virus infection. Arch Neurol. 1992;49:38–43
  39. Moore DJ, Masliah E, Rippeth JD, et al. Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. AIDS. 2006;20:879–887
  40. Wu Y, Storey P, Cohen BA, et al. Diffusion alterations in corpus callosum of patients with HIV. AJNR Am J Neuroradiol. 2006;27:656–660
  41. Ragin AB, Wu Y, Storey P, et al. Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus. J Neurovirol. 2005;11:292–298
  42. Cloak CC, Chang L, Ernst T. Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV. J Neuroimmunol. 2004;157:147–152
  43. Ragin AB, Storey P, Cohen BA, et al. Disease burden in HIV-associated cognitive impairment: A study of whole-brain imaging measures. Neurology. 2004;63:2293–2297
  44. Ragin AB, Storey P, Cohen BA, et al. Whole brain diffusion tensor imaging in HIV-associated cognitive impairment. AJNR Am J Neuroradiol. 2004;25:195–200
  45. Thurnher MM, Schindler EG, Thurnher SA, et al. Highly active antiretroviral therapy for patients with AIDS dementia complex: Effect on MR imaging findings and clinical course. AJNR Am J Neuroradiol. 2000;21:670–678
  46. Bartzokis G, Lu PH, Geschwind DH, et al. Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: Implications for cognitive decline and dementia. Arch Gen Psychiatry. 2006;63:63–72

 Supported by the PhD in Clinical Research Program at the University of Hawaii, 1K07GM072A84. Additional support from National Institute of Neurological Disorders and Stroke (NINDS) grant 1U54NS43049, National Center for Research Resources (NCRR) grant P20 RR11091, and Research Centers in Minority Institutions (RCMI) grant G12 RR/AI 03061.

PII: S1052-3057(08)00066-9

doi: 10.1016/j.jstrokecerebrovasdis.2008.02.005

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 4 , Pages 212-217 , July 2008