Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 331-333 , November 2008

A Risk Score to Predict Intracranial Hemorrhage After Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke

  • Brett Cucchiara, MD

      Affiliations

    • Department of Neurology, University of Pennsylvania Medical Center, Philadelphia
    • Corresponding Author InformationAddress correspondence to Brett Cucchiara, MD, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104.
    • ,
  • David Tanne, MD

      Affiliations

    • Department of Neurology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
    • ,
  • Steven R. Levine, MD

      Affiliations

    • Department of Neurology, Mount Sinai Medical Center, New York, New York
    • ,
  • Andrew M. Demchuk, MD

      Affiliations

    • Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    • ,
  • Scott Kasner, MD

      Affiliations

    • Department of Neurology, University of Pennsylvania Medical Center, Philadelphia

Received 26 February 2008 ,Accepted 18 March 2008.

References 

  1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group . Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–1587
  2. Tanne D, Kasner SE, Demchuk AM, et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: The multicenter rt-pa stroke survey. Circulation. 2002;105:1679–1685
  3. The NINDS rt-PA Stroke Study Group . Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke. 1997;28:2109–2118
  4. Lansberg MG, Albers GW, Wijman CA. Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: A review of the risk factors. Cerebrovasc Dis. 2007;24:1–10
  5. Marti-Fabregas J, Bravo Y, Cocho D, et al. Frequency and predictors of symptomatic intracerebral hemorrhage in patients with ischemic stroke treated with recombinant tissue plasminogen activator outside clinical trials. Cerebrovasc Dis. 2007;23:85–90
  6. Castellanos M, Sobrino T, Millan M, et al. Plasma MMP-9 and fibronectin levels confirm their value as powerful predictors of hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke: A multicenter prospective study. Stroke. 2007;38:463

 Supported by an American Heart Association Fellow-to-Faculty Award (Dr. Cucchiara).

PII: S1052-3057(08)00084-0

doi: 10.1016/j.jstrokecerebrovasdis.2008.03.012

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 331-333 , November 2008

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