Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 344-355 , November 2008

Inflammation and Hemostasis Biomarkers for Predicting Stroke in Postmenopausal Women: The Women's Health Initiative Observational Study

  • Robert C. Kaplan, PhD

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
    • Corresponding Author InformationAddress correspondence to Robert C. Kaplan, PhD, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1306C, Bronx, NY 10461.
  • ,
  • Aileen P. McGinn, PhD

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
  • ,
  • Alison E. Baird, MD

      Affiliations

    • National Institute of Neurological Disorders and Stroke, Stroke Neuroscience Unit, Bethesda, Maryland
  • ,
  • Susan L. Hendrix, DO

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine/Hutzel Women's Hospital, Detroit, Michigan
  • ,
  • Charles Kooperberg, PhD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
  • ,
  • John Lynch, DO, MPH

      Affiliations

    • National Institute of Neurological Disorders and Stroke, Stroke Neuroscience Unit, Bethesda, Maryland
  • ,
  • Daniel M. Rosenbaum, MD

      Affiliations

    • Department of Neurology SUNY Downstate, Brooklyn, New York
  • ,
  • Karen C. Johnson, MD, MPH

      Affiliations

    • University of Tennessee Health Science Center, Memphis, Tennessee
  • ,
  • Howard D. Strickler, MD, MPH

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
  • ,
  • Sylvia Wassertheil-Smoller, PhD

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York

Received 26 November 2007 ,Revised 4 April 2008 ,Accepted 21 April 2008.

References 

  1. Jenny NS, Arnold AM, Kuller LH, et al. Serum amyloid P and cardiovascular disease in older men and women: Results from the cardiovascular health study. Arterioscler Thromb Vasc Biol. 2007;27:352–358
  2. Cushman M, Arnold AM, Psaty BM, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: The cardiovascular health study. Circulation. 2005;112:25–31
  3. Cao JJ, Thach C, Manolio TA, et al. C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: The cardiovascular health study. Circulation. 2003;108:166–170
  4. Revilla M, Obach V, Cervera A, et al. A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction. Neurosci Lett. 2002;324:29–32
  5. Cesari M, Penninx BW, Newman AB, et al. Inflammatory markers and onset of cardiovascular events: Results from the health ABC study. Circulation. 2003;108:2317–2322
  6. Pradhan AD, Manson JE, Rossouw JE, et al. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the women's health initiative observational study. JAMA. 2002;288:980–987
  7. Jenny NS, Tracy RP, Ogg MS, et al. In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2002;22:2066–2071
  8. Tanne D, Haim M, Boyko V, et al. Soluble intercellular adhesion molecule-1 and risk of future ischemic stroke: A nested case-control study from the Bezafibrate infarction prevention (BIP) study cohort. Stroke. 2002;33:2182–2186
  9. Johansson L, Jansson JH, Boman K, et al. Tissue plasminogen activator, plasminogen activator inhibitor-1, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex as risk factors for the development of a first stroke. Stroke. 2000;31:26–32
  10. Pradhan AD, LaCroix AZ, Langer RD, et al. Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women. Circulation. 2004;110:292–300
  11. Jenny NS, Arnold AM, Kuller LH, et al. Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults. J Thromb Haemost. 2006;4:107–113
  12. Cesari M, Penninx BW, Newman AB, et al. Inflammatory markers and cardiovascular disease (the health, aging and body composition [health ABC] study). Am J Cardiol. 2003;92:522–528
  13. Kistorp C, Raymond I, Pedersen F, et al. N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults. JAMA. 2005;293:1609–1616
  14. Danesh J, Wheeler JG, Hirschfield GM, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387–1397
  15. Everett BM, Kurth T, Buring JE, et al. The relative strength of C-reactive protein and lipid levels as determinants of ischemic stroke compared with coronary heart disease in women. J Am Coll Cardiol. 2006;48:2235–2242
  16. Bos MJ, Schipper CM, Koudstaal PJ, et al. High serum C-reactive protein level is not an independent predictor for stroke: The Rotterdam study. Circulation. 2006;114:1591–1598
  17. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: Definitions for use in a multicenter clinical trial; TOAST, trial of Org 10172 in acute stroke treatment. Stroke. 1993;24:35–41
  18. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: Application to clinical and public health practice; a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  19. Harrell FE, Lee KL, Mark DB. Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361–387
  20. Ridker PM, Buring JE, Rifai N, et al. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds risk score. JAMA. 2007;297:611–619
  21. Folsom AR, Rosamond WD, Shahar E, et al. Prospective study of markers of hemostatic function with risk of ischemic stroke: The atherosclerosis risk in communities (ARIC) study investigators. Circulation. 1999;100:736–742
  22. Margolis KL, Manson JE, Greenland P, et al. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: The women's health initiative observational study. Arch Intern Med. 2005;165:500–508
  23. Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: An individual participant meta-analysis. JAMA. 2005;294:1799–1809
  24. Tracy RP, Arnold AM, Ettinger W, et al. The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly: Results from the cardiovascular health study. Arterioscler Thromb Vasc Biol. 1999;19:1776–1783
  25. Kaplan RC, Ho GY, Xue X, et al. Within-individual stability of obesity-related biomarkers among women. Cancer Epidemiol Biomarkers Prev. 2007;16:1291–1293

 The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, US Department of Health and Human Services. The Hormones and Biomarkers Predicting Stroke (HaBPS) Study is funded by the National Institute of Neurological Disorders and Stroke, Bethesda, Md, US Department of Health and Human Services. The funders had no role in the design, conduct, or manuscript preparation for the HaBPS Study.

PII: S1052-3057(08)00086-4

doi: 10.1016/j.jstrokecerebrovasdis.2008.04.006

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 344-355 , November 2008