Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 356-359 , November 2008

Titrated Initiation of Acetylsalicylic Acid-Dipyridamole Therapy Reduces Adverse Effects and Improves Tolerance in Patients With Stroke

  • André G. Douen, MD, PhD, FRCPC

      Affiliations

    • Department of Neurology, Trillium Health Centre, Mississauga, Ontario, Canada
    • Division of Neurology, University of Ottawa, Ontario, Canada
    • Corresponding Author InformationAddress correspondence to André G. Douen, MD, PhD, FRCPC, Director, Regional Stroke Prevention Clinic, Division of Neurology, Trillium Health Centre, 100 Queensway West, Mississauga, ON L5B 1B8 Canada.
    • ,
  • Sejla Medic, RN

      Affiliations

    • Department of Neurology, Trillium Health Centre, Mississauga, Ontario, Canada
    • ,
  • Mehreen Sabih, MBBS

      Affiliations

    • Department of Neurology, Trillium Health Centre, Mississauga, Ontario, Canada
    • ,
  • Nicole Pageau, RN, BA

      Affiliations

    • Department of Neurology, Trillium Health Centre, Mississauga, Ontario, Canada
    • ,
  • Ashfaq Shuaib, MD, FRCPC, FAHA

      Affiliations

    • Division of Neurology, University of Alberta, Edmonton, Canada

Received 14 December 2007 ,Accepted 21 April 2008.

References 

  1. Diener HC, Cunha L, Forbes C, et al. European stroke prevention study 2: Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996;143:1–13
  2. The ESPRIT Study Group. Aspirin and dipyridamole versus aspirin alone after cerebral ischemia of arterial origin (ESPRIT): Randomized controlled trial. Lancet. 2006;367:1665–1673
  3. Kruuse C, Lassen LH, Iversen HK, et al. Dipyridamole may induce migraine in patients with migraine without aura. Cephalalgia. 2006;26:925–933
  4. Lipton RB, Bigal ME, Kolodner KB, et al. Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. Neurology. 2004;63:1099–1101
  5. Lindgren A, Husted S, Staaf G, et al. Dipyridamole and headache–a pilot study of initial dose titration. J Neurol Sci. 2004;223:179–184
  6. Chang YJ, Ryu SJ, Lee TH. Dose titration to reduce dipyridamole-related headache. Cerebrovasc Dis. 2006;22:258–262
  7. Theis JG, Deichsel G, Marshall S. Rapid development of tolerance to dipyridamole-associated headaches. Br J Clin Pharmacol. 1999;48:750–755

 Supported through unrestricted educational grants from Boehringer Ingelheim, Canada (N. Pageau, S. Medic, M. Sabih).

PII: S1052-3057(08)00089-X

doi: 10.1016/j.jstrokecerebrovasdis.2008.04.003

Journal of Stroke & Cerebrovascular Diseases
Volume 17, Issue 6 , Pages 356-359 , November 2008

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