Journal of Stroke & Cerebrovascular Diseases
Volume 18, Issue 5 , Pages 367-373 , September 2009

D-dimer, Magnetic Resonance Imaging Diffusion-weighted Imaging, and ABCD2 Score for Transient Ischemic Attack Risk Stratification

  • Brett L. Cucchiara, MD

      Affiliations

    • University of Pennsylvania, Philadelphia
    • Corresponding Author InformationAddress correspondence to Brett L. Cucchiara, MD, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104.
  • ,
  • Steve R. Messe, MD

      Affiliations

    • University of Pennsylvania, Philadelphia
  • ,
  • Lauren Sansing, MD

      Affiliations

    • University of Pennsylvania, Philadelphia
  • ,
  • Larami MacKenzie, MD

      Affiliations

    • University of Pennsylvania, Philadelphia
  • ,
  • Robert A. Taylor, MD

      Affiliations

    • University of Minnesota, Minneapolis
  • ,
  • James Pacelli, MD

      Affiliations

    • Lancaster General Hospital, Pennsylvania
  • ,
  • Qaisar Shah, MD

      Affiliations

    • Abington Memorial Hospital, Pennsylvania
  • ,
  • Eleanor S. Pollak, MD

      Affiliations

    • University of Pennsylvania, Philadelphia
  • ,
  • Scott E. Kasner, MD

      Affiliations

    • University of Pennsylvania, Philadelphia

Received 4 December 2008 ,Revised 13 January 2009 ,Accepted 20 January 2009.

References 

  1. Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischemic attack. Lancet. 2007;369:283–292
  2. Feinberg WM, Erickson LP, Bruck D, et al. Hemostatic markers in acute ischemic stroke: Association with stroke type, severity, and outcome. Stroke. 1996;27:1296–1300
  3. Kataoka S, Hirose G, Hori A, et al. Activation of thrombosis and fibrinolysis following brain infarction. J Neurol Sci. 2000;181:82–88
  4. Fon EA, Mackey A, Cote R, et al. Hemostatic markers in acute transient ischemic attacks. Stroke. 1994;25:282–286
  5. Cote R, Wolfson C, Solymoss S, et al. Hemostatic markers in patients at risk of cerebral ischemia. Stroke. 2000;31:1856–1862
  6. Montaner J, Perea-Gainza M, Delgado P, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke. 2008;39:2280–2287
  7. Bayes-Genis A, Mateo J, Santalo M, et al. D-dimer is an early diagnostic marker of coronary ischemia in patients with chest pain. Am Heart J. 2000;140:379–384
  8. Ottani F, Galvani M. Prognostic role of hemostatic markers in acute coronary syndromes patients. Clin Chim Acta. 2001;311:33–39
  9. Moss AJ, Goldstein RE, Marder VJ, et al. Thrombogenic factors and recurrent coronary events. Circulation. 1999;99:2517–2522
  10. Stein PD, Hull RD, Patel KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: A systematic review. Ann Intern Med. 2004;140:589–602
  11. Giles MF, Rothwell PM. Risk of stroke early after transient ischemic attack: A systematic review and meta-analysis. Lancet Neurol. 2007;6:1063–1072
  12. Koton S, Rothwell PM. Performance of the abcd and abcd2 scores in TIA patients with carotid stenosis and atrial fibrillation. Cerebrovasc Dis. 2007;24:231–235
  13. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–453
  14. Rothwell PM, Eliasziw M, Gutnikov SA, et al. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet. 2004;363:915–924
  15. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857–867
  16. Cucchiara BL, Messe SR, Taylor RA, et al. Is the abcd score useful for risk stratification of patients with acute transient ischemic attack?. Stroke. 2006;37:1710–1714
  17. Kasner SE, Kimmel SE. Accuracy of initial stroke subtype diagnosis: A decision analysis. Cerebrovasc Dis. 2000;10:18–24
  18. Hankey GJ. Management of the first-time transient ischemic attack. Emerg Med (Fremantle). 2001;13:70–81
  19. Johnston SC, Gress DR, Browner WS, et al. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284:2901–2906
  20. Limpert E, Stahel W, Abbt M. Log-normal distributions across the sciences: Keys and clues. BioScience. 2001;51:341–352
  21. Purroy F, Montaner J, Rovira A, et al. Higher risk of further vascular events among transient ischemic attack patients with diffusion-weighted imaging acute ischemic lesions. Stroke. 2004;35:2313–2319
  22. Coutts SB, Simon JE, Eliasziw M, et al. Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging. Ann Neurol. 2005;57:848–854
  23. Redgrave JN, Schulz UG, Briley D, et al. Presence of acute ischemic lesions on diffusion-weighted imaging is associated with clinical predictors of early risk of stroke after transient ischemic attack. Cerebrovasc Dis. 2007;24:86–90
  24. Calvet D, Lamy C, Touze E, et al. Management and outcome of patients with transient ischemic attack admitted to a stroke unit. Cerebrovasc Dis. 2007;24:80–85
  25. Cook NR. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation. 2007;115:928–935

 Supported by an American Heart Association Fellow-to-Faculty Transition Award (Dr. Cucchiara).

PII: S1052-3057(09)00021-4

doi: 10.1016/j.jstrokecerebrovasdis.2009.01.006

Journal of Stroke & Cerebrovascular Diseases
Volume 18, Issue 5 , Pages 367-373 , September 2009