Journal of Stroke & Cerebrovascular Diseases
Volume 19, Issue 1 , Pages 29-35 , January 2010

A Randomized Controlled Trial of the Effect of Fixed-dose Routine Nocturnal Oxygen Supplementation on Oxygen Saturation in Patients with Acute Stroke

  • Christine Roffe, MD

      Affiliations

    • Stroke Research Group, Keele University, Staffordshire, United Kingdom
    • Institute for Life Courses Studies, Keele University, Staffordshire, United Kingdom
    • Corresponding Author InformationAddress correspondence to Christine Roffe, MD, Stroke Research office, Royal Infirmary, University Hospital of North Staffordshire, Stoke-on-Trent, ST4 7LN, United Kingdom.
    • ,
  • Sheila Sills, MPhil

      Affiliations

    • Stroke Research Group, Keele University, Staffordshire, United Kingdom
    • ,
  • Sarah J. Pountain, PhD

      Affiliations

    • Institute for Life Courses Studies, Keele University, Staffordshire, United Kingdom
    • ,
  • Martin Allen, FRCP

      Affiliations

    • Department of Respiratory Medicine, University Hospital of North Staffordshire, Staffordshire, United Kingdom

Received 18 September 2008 ,Revised 3 February 2009 ,Accepted 11 February 2009.

References 

  1. Stroke Unit Trialists' Collaboration Organized inpatient (stroke unit) care for stroke. Stroke unit trialists' collaboration organized inpatient care for stroke. Cochrane Database of Systematic Reviews. 2007;(Issue 4):Art. no. CD 000197. DOI: 10.1002/14561858. CD 000197. Pub 2
  2. Indredavik B, Bakke F, Slordahl SA, et al. Treatment in a combined acute and rehabilitation stroke unit: Which aspects are most important?. Stroke. 1999;30:917–923
  3. Roffe C. Hypoxemia and stroke. Rev Clin Gerontol. 2001;11:323–335
  4. Lewis LD, Ponten U, Siesjo BK. Homeostatic regulation of brain energy metabolism in hypoxia. Acta Physiol Scand. 1973;88:284–286
  5. Nakajima S, Meyer JS, Amano T, et al. Cerebral vasomotor responsiveness during 100% oxygen inhalation in cerebral ischemia. Arch Neurol. 1983;40:271–276
  6. Yager JY, Thornhill JA. The effect of age on susceptibility to hypoxic-ischemic brain damage. Neurosci Biobehav Rev. 1997;21:167–174
  7. Yamamoto M, Meyer JS, Sakai F, et al. Aging and cerebral vasodilator responses to hypercarbia: Responses in normal aging and in persons with risk factors for stroke. Arch Neurol. 1980;37:489–496
  8. Roffe C, Sills S, Halim M, et al. Unexpected nocturnal hypoxia in patients with acute stroke. Stroke. 2003;34:2641–2645
  9. Arora A, Gray R, Crome P, et al. British Association of Stroke Physicians (BASP) members' views on oxygen treatment in acute stroke. Age Ageing. 2003;32:41;(abstr) (suppl)
  10. Ogburn-Russell L, Johnson JE. Oxygen saturation levels in the well elderly: Altitude makes a difference. J Gerontol Nurs. 1990;16:26–30
  11. Leach RM, Bateman NT. Acute oxygen therapy. Br J Hosp Med. 1993;49:637–644
  12. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159–163
  13. Ronning OM, Guldvog B. Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke. 1999;30:2033–2037
  14. Thorvaldsen P, Asplund K, Kuulasmaa K, et al. Stroke incidence, case fatality, and mortality in the WHO MONICA project: World Health Organization monitoring trends and determinants in cardiovascular disease. Stroke. 1995;26:361–367
  15. Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. 1991;337:1521–1526
  16. Roffe C, Sills S, Wilde K, et al. Effect of hemiparetic stroke on pulse oximetry readings on the affected side. Stroke. 2001;32:1808–1810
  17. Rowat AM, Dennis MS, Wardlaw JM. Hypoxemia in acute stroke is frequent and worsens outcome. Cerebrovasc Dis. 2006;21:166–172
  18. Rawles JM, Kenmure AC. Controlled trial of oxygen in uncomplicated myocardial infarction. Br Med J. 1976;1:1121–1123
  19. Singhal AB, Benner T, Roccatagliata L, et al. A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke. 2005;36:797–802

 North Staffordshire Medical Institute funded the purchase of the pulse oximeters.

PII: S1052-3057(09)00044-5

doi: 10.1016/j.jstrokecerebrovasdis.2009.02.008

Journal of Stroke & Cerebrovascular Diseases
Volume 19, Issue 1 , Pages 29-35 , January 2010

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