Journal of Stroke & Cerebrovascular Diseases
Volume 19, Issue 1 , Pages 66-72 , January 2010

Prognostic Role of Mean Platelet Volume and Platelet Count in Ischemic and Hemorrhagic Stroke

Received 13 February 2009 ,Accepted 6 March 2009.

References 

  1. Greisenegger S, Endler G, Hsieh K, et al. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?. Stroke. 2004;34:1688–1691
  2. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157–161
  3. Kamath S, Blann AD, Lip GY. Platelet activation: Assesment and quantification. Eur Heart J. 2001;22:1561–1571
  4. Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002;117:399–404
  5. Jagroop IA, Tsiara S, Mikhailidis DP. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets. 2003;14:335–336
  6. Tsiara S, Elisaf M, Jagroop IA, et al. Platelets as predictors of vascular risk: Is there a practical index of platelet activity?. Clin Appl Thromb Hemost. 2003;9:177–190
  7. Jakubowski JA, Thomson CB, Vaillancourt R, et al. Arachidonic acid metabolism by platelets of differing size. Br J Haematol. 1983;53:503–511
  8. Martin JF, Shaw T, Heggie J, et al. Measurement of the density of platelets and its relationship to volume. Br J Haematol. 1983;54:337–352
  9. Kristensen SD. The platelets vessel wall interaction in experimental atherosclerosis and ischemic heart disease with special reference to thrombopoises. Dan Med Bull. 1992;39:110–127
  10. O'Malley T, Langhorne P, Elton RA, et al. Platelet size in stroke patients. Stroke. 1995;26:995–999
  11. Muscari A, Puddu DM, Cenni A, et al. Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res. 2009;123:587–591
  12. O'Brien JR, Jamieson S. A relationship between platelet volume and platelet number. Thromb Diath Haemorrh. 1974;31:363–364
  13. Bessman JD. The relation of megakaryocyte ploidy to platelet volume. Am J Hematol. 1984;16:161–170
  14. Brown AS, Hong Y, de Belder A, et al. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol. 1997;17:802–807
  15. Tscoepe D, Esser J, Schwippert B, et al. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost. 1991;17:433–439
  16. Kario K, Matsu OT, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14:281–287
  17. Kurabayashi H, Tamura J, Naruse T, et al. Possible existence of platelet activation before onset of cerebral infarction. Atherosclerosis. 2000;153:203–207
  18. O'Brien JR. The role of platelets in the thrombotic diasthesis. Blood Vessels. 1980;11:1–15
  19. Halbmayer WM, Haushofer A, Radek J, et al. Platelet size, fibrinogen and lipoprotein (a) in coronary heart disease. Coron Artery Dis. 1995;6:397–402
  20. Butterworth R, Bath P. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets. 1998;9:359–364
  21. D'Erasmo E, Aliberti G, Celi F. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med. 1990;227:11–14
  22. Fang HY, Lin CY, Ko WJ. Hematology and coagulation parameters predict outcome in Taiwanase patients with spontaneous intracerebral hemorrhage. Eur J Neurol 1005;12:226–232.
  23. Rajajee V, Brown DM, Tuhrim S. Coagulation abnormalities following primary intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2004;13:47–51
  24. Smith NM, Pathensali R, Bath PMW. Platelets and stroke. Vasc Med. 1999;4:165–172
  25. Hatano S. Experience from a multicentre stroke register: A preliminary report. Bull World Health Organ. 1976;54:541–553
  26. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: Definitions for use in a multicenter clinical trial. Stroke. 1993;24:35–41
  27. Beamer NB, Coull BM, Clark WM, et al. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol. 1995;37:800–804
  28. Ziai WC, Torbey MT, Kickler TS, et al. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2003;12:201–206
  29. del Zoppo GJ. The role of platelets in ischemic stroke. Neurology. 1998;51:9–14
  30. Furiozzi F. Mean platelet volume and acute ischemic stroke. Stroke. 1996;27:1010–1011
  31. McCabe DJH, Harrison P, Sidhu PS, et al. Circulating reticulated platelets in the early and late phases after ischemic stroke and transient ischemic attack. Br J Haematol. 2004;126:861–869
  32. Nadar SK, Gregory YH, Blann AD. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischemic stroke. Thromb Haemost. 2004;92:1342–1348
  33. Tohgi H, Suzuki H, Tamura K, et al. Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke. 1991;22:17–21
  34. Bath PM. The routine measurement of platelet size using sodium citrate alone as the anticoagulant. Thromb Haemost. 1993;70:687–690
  35. Threatte GA. Usefulness of the mean platelet volume. Lin Lab Med. 1993;13:937–950
  36. Kılıçlı-Çamur N, Demirtunç R, Konuralp C, et al. Could mean platelet volume be a predictive marker for acute myocardial infarction?. Med Sci Monit. 2005;11:387–392
  37. Pathansali R, Smith N, Bath P. Altered megakaryocyte-platelet hemostatic axis in hypercholesterolemia. Platelets. 2001;12:292–297
  38. Bath PM, Carney C, Markandu ND, et al. Platelet volume is not increased in essential hypertension. J Hum Hypertens. 1994;8:457–459
  39. Yazbek N, Bapat A, Kleiman N. Platelet abnormalities in diabetes mellitus. Coron Artery Dis. 2003;14:365–371
  40. Gonzalez-Duarte A, Garcia-Ramos GS, Valdes-Ferrer SI, et al. Clinical description of intracranial hemorrhage associated with bleeding disorders. J Stroke Cerebrovasc Dis. 2008;17:204–207
  41. Bath P, Algert C, Chapman N, et al. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke. 2004;35:622–626
  42. Gaur SP, Gang RK, Agarwal S, et al. Platelet functions and lipid profile within 24 hours following an attack of TIA, thrombotic and hemorrhagic stroke. Indian J Med Res. 1994;99:259–263
  43. Lui L, Lin Z, Zheshuang S, et al. Platelet hyperfunction exists in both acute non-hemorrhagic and hemorrhagic stroke. Thromb Res. 1994;75:485–490
  44. Sansing LH, Kaznatcheeva EA, Perkins CJ, et al. Edema after intracerebral hemorrhage: Correlations with coagulation parameters and treatment. J Neurosurg. 2003;98:985–992

PII: S1052-3057(09)00047-0

doi: 10.1016/j.jstrokecerebrovasdis.2009.03.003

Journal of Stroke & Cerebrovascular Diseases
Volume 19, Issue 1 , Pages 66-72 , January 2010

Article Tools

* Image Usage & Resolution