Abstract
This preliminary study investigates the risk factor profile, post stroke complications,
and outcome for four OCSP (Oxfordshire Community Stroke Project Classification) subtypes.
One hundred seventeen consecutive ischemic stroke patients were clinically classified
into 1 of 4 subtypes: total anterior (TACI), partial anterior (PACI), lacunar (LACI),
and posterior (POCI) circulation infarcts. Study evaluations were performed at admission,
2 weeks, and 6 months. There was a good correlation between clinical classification
and radiological diagnosis if a negative CT head was considered consistent with a
lacunar infarction. No significant difference in risk factor profile was observed
between subtypes. The TACI group had significantly higher mortality (P <.001), morbidity (P <.001, as per disability scales), length of hospital stay (P <.001), and complications (respiratory tract infection and seizures [P <.01]) as compared to the other three groups which were all similar at the different
time points. The only significant difference found was the higher rate of stroke recurrence
within the first 6 months in the POCI group (P <.001). The OCSP classification identifies two major groups (TACI and other 3 groups
combined) who behave differently with respect to post stroke outcome. Further study
with larger numbers of patients and thus greater power will be required to allow better
discrimination of OCSP subtypes in respect of risk factors, complications, and outcomes
if the OCSP is to be used to stratify patients in clinical trials. Copyright © 2003
by National Stroke Association
Keywords
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Article info
Publication history
Accepted:
October 4,
2002
Received:
August 27,
2002
Footnotes
*Supported in part by a grant from Schering AG, Ireland (S. J. P.).
**Address reprint requests to Sean J. Pittock, MD, Department of Neurology, 200 First Street SW, Mayo Clinic, Rochester, MN 55901.
Identification
Copyright
© 2003 National Stroke Association. Published by Elsevier Inc. All rights reserved.
