A 69-year-old man presented to our hospital with an acute aphaisa. The patient had experienced headaches 27 months before this presentation and a magnetic resonance image (MRI) had been normal at that time. After a normal unenhanced head computed tomography (CT) scan was obtained, he received intravenous tissue plasminogen activator (t-PA) within 2 hours of the onset of his symptoms. The patient gradually improved, but on day 13, post t-PA–increased somnolence was noted. A repeat head CT scan showed acute hydrocephalus and a mass. The tumor did not respond to radiation treatment and the patient died 39 days after the initial presentation.
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- Glioblastoma multiforme. Review of 219 cases with regard to natural history, pathology, diagnostic methods, and treatment.J Neurosurg. 1958; 15: 489-503
- Computed tomography in the diagnosis and differential diagnosis of glioblastomas. A qualitative study of 295 cases.Neuroradiology. 1977; 14: 193-200
- Expression of heterogenous profile of plasminogen activators and plasminogen activator inhibitors by human glioma lines.Cancer Res. 1990; 50: 4957-4961
- Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human brain tumors.Cancer Res. 1994; 54: 1105-1108
- Up-regulation of urokinase receptor genes in malignant astrocytoma.Am J Pathol. 1995; 146: 1150-1160
- VEGF and t-PA co-expressed in malignant glioma.Acta Oncologica. 1997; 36: 615-618
- Sustained fibrinolysis after administration of t-PA despite its short half-life in the circulation.Thromb Haemost. 1987; 57: 35-40
Accepted: October 16, 2002
Received: June 4, 2002
*Address reprint requests to: Hans H. Klüenemann, MD, University of Regensburg School of Medicine, Department of Psychiatry, Universitatsstr 84, D-93053, Regensburg, Germany.
© 2003 National Stroke Association. Published by Elsevier Inc. All rights reserved.