This paper is only available as a PDF. To read, Please Download here.
Carotid artery surgical specimens from 15 consecutive patients undergoing carotid endarterectomy were studied in an attempt to identify morphologic differences between carotid artery plaque neovascularization (NV) and normal vasa vasorum (VV). The patients included 12 men and 3 women with an age range of 55-81 years (mean, 67). Nine of them had ischemic symptoms directly related to the plaque being removed. The specimens were stained with hematoxylin-eosin, Verhoef-Van Gieson, and factor VIII-related antigen techniques. In addition, normal carotid arteries were obtained for comparison from two autopsies of young individuals, victims of traumatic death. The severity of NV within the plaque was graded based on the appearance and location of new vessels, as they compared to W. Mild NV (Grade I) was found in 3/15, whereas moderate and severe (Grades II and III) were each found in 6/15 cases. Increasing severity of NV was associated with more tortuosity, thicker walls, and location closer to the carotid lumen. The presence and severity of NV did not correlate with plaque thickness (p = 0.2), the presence of symptoms (p = 0.5), or any other risk factors for stroke. Carotid plaque NV seems independent of the degree of atheroma and morphologically different than VV. Its origin, true incidence, and role in the production of carotid intraplaque hemorrhage and increased stroke risk are still uncertain. This is the first immunohistochemical study of carotid plaque neovascularization.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Stroke and Cerebrovascular Diseases
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Carotid plaque morphology and risk for stroke.Stroke. 1990; 21: 148-151
- The carotid bifurcation plaque: pathologic findings associated with cerebral ischemia.Stroke. 1979; 10: 238-245
- The importance of hemorrhage in the relationship between gross morphologic characteristics and cerebral symptoms in 376 carotid artery plaques.Ann Surg. 1983; 197: 195-203
- Carotid intraplaque hemorrhage: the significance of neovascularity.J Vase Surg. 1987; 6: 341-349
- Hypothesis: vasa vasorum and neovascularization of human coronary arteries.N Engl J Med. 1984; 310: 175-177
- Vasculature in the walls of the human coronaries.Arch Pathol Lab Med. 1985; 109: 659-662
- Neovascularization and coronary atherosclerotic plaque: cinematographic localization and quantitative histologic analysis.Hum Pathol. 1987; 18: 1036-1042
- The origin and distribution of the vasa vasorum of the carotid bifurcation.Stroke. 1989; 20: 1484-1487
- Factor VIII-related antigen as an endothelial cell marker in benign and malignant diseases.Virchows Arch [A]. 1981; 391: 217-225
- Clinical significance of carotid plaque hemorrhage.Arch Neurol. 1990; 47: 958-959
© 1992 National Stroke Association. Published by Elsevier Inc. All rights reserved.