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We studied the effects of the calcium channel antagonist nimodipine on the evolution
of hemorheological variables during the first 3 weeks following ischemic stroke. We
studied 13 patients and found that, compared to baseline levels, plasma fibrinogen
concentration and low-shear whole-blood viscosity rose significantly in patients receiving
placebo but not in those receiving nimodipine. Red blood cell aggregation rose in
both groups but less so in nimodipine-treated patients. Hematocrit, high-shear whole-blood
viscosity, and red blood cell deformability did not change significantly in either
group. In conclusion, the use of nimodipine appears to alter the evolution of some
hemorheological variables following acute ischemic stroke.
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© 1992 National Stroke Association. Published by Elsevier Inc. All rights reserved.
