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Research Article| Volume 2, ISSUE 1, P34-39, 1992

Aseptic cerebral venous thrombosis: Proposed prognostic scale

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      Seventy-eight patients with aseptic cerebral venous thrombosis between 1966 and 1990 were reviewed in order to determine prognostic factors for this condition. Sixty-eight patients were women. The average age of the patients was 30.5 years. Fifty-two percent of patients developed the thrombosis during the postpartum or puerperal stage. The clinical manifestations that were associated with a poor prognosis were: stupor or coma, bilateral pyramidal tract signs, generalized seizures, meningeal signs, bilateral lesions on computed tomography, and hemorrhagic cerebrospinal fluid. Using these clinical features, a prognostic scale is proposed with a positive predictive value of 0.98 for a good prognosis and 0.96 for a poor prognosis.

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      References

        • Kendall D
        Thrombosis of intracranial veins.
        Brain. 1948; 71: 386-442
        • Srinivasan K
        Cerebral venous and arterial thrombosis in pregnancy and pueperium. A study of 135 patients.
        Angiology. 1983; 34: 733-746
        • Donaldson JO
        Donaldson JO Cerebral venous thrombosis. Neurology of pregnancy. 7. W.B. Saunders, Philadelphia1978: 135-156
        • Cross JN
        • Castro PO
        • Jennett WB
        Cerebral strokes associated with pregnancy and puerperium.
        Br Med J. 1968; 3: 214-218
        • Srinivasan K
        Puerperal cerebral venous and arterial thrombosis.
        Sem Neurol. 1988; 8: 222-225
        • Dubois J
        Les thromboflebites cerebrales du postpartum.
        Gynecol Obstet. 1956; 55: 472-493
        • Carroll JD
        • Leak D
        • Lee HA
        Cerebral thrombophlebitis in pregnancy and the puerperium.
        Q J Med. 1966; 35: 347-368
        • Krayenbuhl HA
        Cerebral venous and sinus thrombosis.
        Clin Neurosurg. 1966; 14: 1-24
        • Bousser MG
        • Chiras J
        • Bories J
        • et al.
        Cerebral venous thrombosis. A review of 38 cases.
        Stroke. 1985; 16: 199-213
        • Gates PC
        • Barnett HJM
        Barnett HJM Mohr JP Stein B Yatsu FM Venous disease: cortical veins and sinuses. Stroke: pathophysiology, diagnosis and management. vol 2. Churchill-Livingstone, New York1986: 731-746
        • Rousseaux P
        • Bernard MH
        • Sherpereel B
        • et al.
        Thrombose des sinus veineux intra-craniene (a propos de 22 cas).
        Neurochirugie. 1978; 24: 197-203
        • Kinal ME
        Traumatic thrombosis of dural venous sinuses in closed head injuries.
        J Neurosurg. 1967; 27: 142-145
        • Stringer WL
        • Peerless SJ
        Superior sagittal sinus thrombosis after closed head injuries.
        Neurosurgery. 1983; 12: 95-97
        • Crimmins TJ
        • Rokswold GL
        • Yock DH
        Progressive posttraumatic superior sagittal-Sinus thrombosis complicated by pulmonary embolism.
        J Neurosurg. 1984; 60: 179-182
        • Sigsbee B
        • Deck M
        • Posner JB
        Nonmetastasic superior sagittal sinus thrombosis complicating systemic cancer.
        Neurology. 1979; 29: 139-146
        • Buchanan DS
        • Brazomslu JH
        Dural sinus and cerebral venous thrombosis. Incidence in young women receiving oral contraceptives.
        Arch Neurol. 1970; 22: 440-444
        • Atkinson WA
        • Farburn B
        • Heathfield KN
        Intracranial venous thrombosis as complication of oral contraception.
        Lancet. 1970; 1: 914-918
        • Estanol B
        • Rodriguez A
        • Conte B
        • et al.
        Intracranial venous thrombosis in young women.
        Stroke. 1979; 10: 680-681
        • Schaffer AL
        The hypercoagulable states.
        Ann Intern Med. 1985; 102: 814-828
        • Kitchens CS
        Concept of hypercoagulability: a review of the development, clinical application and recent progress.
        Semin Thromb Hetnost. 1985; 11: 591-609
        • Harris EN
        • Gharavi AE
        • Hughes GR
        Anti-phospholipid antibodies.
        Clin Rheumttnol Dis. 1985; 11: 591-609
        • Levine SR
        • Welch KM
        The spectrum of neurologic disease associated with antiphospholipid antibodies.
        Arch Neurol. 1987; 44: 876-883
        • Ashersoh RA
        • Khamashta MA
        Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erithematosus, lupus-like disease and the primary antiphospholipid syndrome.
        Am J Med. 1989; 86: 391-399
        • Kalbag RM
        Kapp JP Schmideck HH Cerebral venous thrombosis. Tlie cerebral venous system and its disorders. Grune & Stratton, Orlando, FL1984: 505-536
        • Imai WK
        • Everhart FR
        • Sanders MG
        Cerebral venous sinus thrombosis: report of a case and review of the literature.
        Pediatrics. 1982; 70: 965-970
        • Averback P
        Primary cerebral venous thrombosis in young adults: the diverse manifestations of an underrecognized disease.
        Ann Neurol. 1978; 3: 81-86
        • Gettelfinger DM
        • Kokmen E
        Superior sagittal sinus thrombosis.
        Arch Neurol. 1977; 34: 2-6
        • Vines FS
        • Davis DO
        Clinical-radiological correlation in cerebral venous occlusive disease.
        Radiology. 1971; 98: 9-22
        • Gabrielsen TU
        • Heinz E
        Spontaneous aseptic thrombosis of the superior sagittal sinus and cerebral veins.
        Am J Roentgenol. 1969; 107: 579-588
        • Nishimura RN
        • Stepanek D
        • Howieson J
        Internal cerebral vein thrombosis. A case report.
        Arch Neurol. 1982; 39: 439-440
        • Yanez Bana RM
        • Rossi Lopez RE
        • Romero J
        • et al.
        Trombosis venosa profunda en relacion a traumatismo craneoencefalico.
        Neurologia (Spain). 1989; 7: 256-259
        • Virapongse C
        • Cazenove C
        • Quisling R
        • et al.
        The empty delta sign: frequency and significance in 76 cases of dural sinus thrombosis.
        Radiology. 1983; 187: 779-785
        • Buonanno FS
        • Moody DM
        Computed cranial tomographic findings in cerebral sinovenous occlusion.
        J Comput Assist Tomogr. 1979; 2: 281-290
        • Goldberg HI
        • Lee SH
        Lee SH Rao K Cerebral venous thrombosis. Cranial computed tomography and MRI. McGraw-Hill, New York1983: 693-699
        • Wendling LR
        Intracranial venous sinus thrombosis: diagnosis suggested by computed tomography.
        Am J Roentgenol. 1978; 130: 978-980
        • Patronas MJ
        • Duda EE
        • Wollman RL
        • et al.
        Sagittal sinus thrombosis diagnosed by computed tomography.
        Surg Neurol. 1981; 15: 11-14
        • Brant-Zawadsky
        • Chan M
        • McCarty GE
        Computed tomography in dural sinus thrombosis.
        Arch Neurol. 1982; 39: 446-447
        • Kingley DP
        • Kendall BE
        • Moseley IF
        Superior sagittal sinus thrombosis: an evaluation of the changes demonstrated on computed tomography.
        J Neurol Neurosurg Psychiatry. 1978; 41: 1055-1058
        • Roa KC
        • Knipp HC
        • Wagner EG
        Computed tomographic findings in cerebral sinus and venous thrombosis.
        Radiology. 1981; 140: 391-398
        • Chiras J
        • Bousser MG
        • Meder JF
        • et al.
        CT in cerebral thrombophlebitis.
        Neuroradiology. 1985; 27: 145-154
        • Guldberg AL
        • Rosenbaum JF
        Computed tomography of dural sinus thrombosis.
        J Comput Assist Tomogr. 1986; 10: 16-20
        • Chiras J
        • Dubs M
        • Boris J
        Venous infarctions.
        Neuroradiology. 1985; 27: 593-600
        • Gomori JM
        • Grossman RI
        Intracranial hematomas: imaging by high-field M.R.
        Radiology. 1985; 157: 87-93
        • Ramadan NM
        • Deveshwar R
        • Levine S
        Magnetic resonance and clinical cerebrovascular disease: an update.
        Stroke. 1989; 20: 1279-1283
        • Bradley WG
        • Waluch V
        Blood flow: magnetic resonance imaging.
        Radiology. 1985; 154: 443-458
        • Baver WM
        • Einhaupl K
        MR of venous sinus thrombosis: a case report.
        Am J Neuroradiol. 1987; 8: 713-715
        • McMurdo SK
        • Brant-Zawadsky M
        Dural sinus thrombosis: study using intermediate field strength MR imaging.
        Radiology. 1986; 161: 83-86