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Plasma big-endothelin (BE) in 12 patients with acute severe ischemic stroke was studied.
Six patients developed complete supratentorial infarctions, and six patients had severe
infarctions of pons, cerebellum, and/or medulla. Significant elevations of BE during
the first 2 weeks after the initial stroke and significant differences between the
pathophysiological subgroups of stroke did not occur. Only patients with a poor outcome
showed significant elevations of BE in contrast to patients with a better prognosis
(p ≤ 0.05). Patients with supratentorial infarctions demonstrated a tendency of higher
BE levels than patients with infratentori-al stroke (p ≤ 0.07). These results support the theory that endothelins represent the amount of
damaged cerebral tissue rather than the endothelium leakage. Low endothelin concentrations
may play a role in local vasodilation and reperfusion.
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© 1993 Published by Elsevier Inc.
