Background
Magnetic resonance–diffusion tensor imaging (DTI) was used to predict motor outcome
for patients with intracerebral hemorrhage. We compared the predictive accuracy of
data sampled from the cerebral peduncle with data from the corona radiata/internal
capsule. This study included 32 subjects with thalamic or putaminal hemorrhage or
both.
Methods
DTI data were obtained on days 14 to 18. Mean values of fractional anisotropy (FA)
within the cerebral peduncle and the corona radiata/internal capsule were analyzed
using a computer-automated method. Applying ordinal logistic regression analyses,
the ratios between FA values in the affected and unaffected hemisphere (rFA) were
modeled in relation to motor outcome scores at 1 month after onset, assessed using
the Medical Research Council (MRC) scale (0 = null to 5 = full).
Results
For both cerebral peduncle and corona radiata/internal capsule, the relationships
between rFA and MRC matched logistic probabilities. While cerebral peduncle rFA values
had statistically significant relationships with MRC scores (upper extremity R2 = 0.271; lower extremity R2 = 0.191), rFA values for the corona radiata/internal capsule showed less significant
relationships (upper extremity R2 = 0.085; lower extremity R2 = 0.080). When estimated cerebral peduncle rFA values were <0.7, estimated probability
of MRC 0 to 2 was close to 85% for the upper and 60% for the lower extremities. Meanwhile,
when estimated rFA values were >0.9, estimated probability for MRC 4 to 5 nearly equaled
50% for the upper and 60% for the lower extremities.
Conclusions
FA values from within the cerebral peduncle more accurately predicted motor outcome
and is a promising technique for clinical application.
Key Words
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Article info
Publication history
Published online: July 27, 2011
Accepted:
June 14,
2011
Received in revised form:
June 12,
2011
Received:
May 6,
2011
Footnotes
Supported by the Medical Research Fund of the Hyogo Medical Association (MRF-H-06-10).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.06.014
Copyright
© 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.
