Background
To investigate the relationship between the HindIII polymorphism and hypertensive intracerebral hemorrhage (HIH) and lipid metabolism.
Methods
A polymerase chain reaction–restriction fragment length polymorphism assay and the
chain termination DNA sequencing method were used to determine the HindIII genotypes of 267 subjects, which included 120 cerebral hemorrhagic patients and
147 controls. The fasting levels of lipids and glucose in the plasma were used to
measure the effect of genotype on HIH risk factors.
Results
The frequency of the T allele of the HindIII polymorphism in the HIH group was 90.8%. The frequency of the G allele was 9.2%.
In the control group, the frequencies were 82.3% T and 17.7% G, which indicated that
the proportion of the G allele in the HIH patient group was significantly lower than
in the control group (P < .05). The frequency of GG + GT genotypes in HIH patients (P < .05) and the plasma triglyceride (TG) levels in these patients (P < .05) were also lower than in the control group. The levels of plasma TG, low-density
lipoprotein cholesterol, glucose, systolic blood pressure, and diastolic blood pressure
in the HIH group were higher than in the controls (P < .05). After controlling for risk factors related to HIH, the HindIII G allele was negatively correlated with the incidence of HIH (odds ratio = .417,
95% confidence interval: .193-.901).
Conclusions
The HindIII G allele may be a protective factor against the development of HIH among the Han
Chinese population.
Key Words
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Article info
Publication history
Published online: January 24, 2014
Accepted:
October 23,
2013
Received:
September 25,
2013
Footnotes
Grant support: Medical leading co-operative project in the third period supported by Songjiang district health bureau of Shanghai City (No.2012-III-13).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.10.024
Copyright
© 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
