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- Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke.Stroke. 2008; 39: 1409-1413
- Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke.Neurology. 2009; 72: 1403-1410
- Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race.Stroke. 2009; 40: 530-536
- Pathogenesis of leukoaraiosis: a review.Stroke. 1997; 28: 652-659
- Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications.Cerebrovasc Dis. 2005; 22: 83-90
- Treatment of leukoaraiosis: a futuristic view.Curr Drug Targets. 2007; 8: 839-845
- Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leukoaraiosis.J Neurol Neurosurg Psychiatry. 2010; 81: 192-197
- Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?.Stroke. 2003; 34: 806-812
- Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtype.Stroke. 2008; 39: 1327-1332
- Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia.J Cereb Blood Flow Metab. 2006; 26: 1274-1284
- Correlation of NO metabolites and 8-iso prostaglandin F2a with periventricular hyperintensity severity.Arterioscler Thromb Vasc Biol. 2004; 24: 1659-1663
- Magnetic resonance imaging white matter hyperintensities in clinically normal elderly individuals: correlations with plasma concentrations of naturally occurring antioxidants.Stroke. 1996; 27: 2043-2047
- Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans.Arterioscler Thromb Vasc Biol. 2005; 27: 279-286
- Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.Curr Opin Investig Drugs. 2009; 10: 644-654
- Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion.J Neurosci Res. 2006; 83: 285-291
- Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents.Stroke. 2006; 37: 2816-2823
- Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment.Stroke. 2011; 42: 1345-1350
Furie KL. Oxidative stress and MMPs (2006). Available at: http://projectreporter.nih.gov/project_info_description.cfm?aid=7138842&icde=130559652006.
Gurol ME, Bottiglieri T, Diaz-Arrastia R, et al. Homocysteine, brain atrophy, and white matter disease in Alzheimer’s disease and cerebral amyloid angiopathy. American Neurological Association Annual Meeting 2004, Toronto, Canada.
- White matter hyperintensity volume is increased in small vessel stroke subtypes.Neurology. 2010; 75: 1670-1677
- Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter.J Cereb Blood Flow Metab. 2001; 21: 828-834
- Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke.Neurol Sci. 2007; 28: 165-170
- Blood-brain barrier breakdown in acute and chronic cerebrovascular disease.Stroke. 2011; 42: 3323-3328
- Chemical events behind leukoaraiosis: medicinal chemistry offers new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype).Curr Med Chem. 2007; 14: 1027-1036
Z.A.C. and N.S.R. contributed equally and share first authorship.
Sources of funding: Funding provided by the Sarnoff Cardiovascular Research Foundation (Z.A.C.); NIH SPOTRIAS grant P50NS051343 (K.L.F.); NIH National Institute of Neurological Disorders and Stroke (NINDS) K23NS064052 and R01NS082285 (N.S.R.); the American Stroke Association–Bugher Foundation (K.L.F., E.H.L., and N.S.R.); and The Deane Institute for Integrative Study of Atrial Fibrillation and Stroke at MGH (K.A. and K.L.F.).
Conflict of interest/disclosure: None.