Background
Epidemiologic studies have elucidated that the 1425G/A single-nucleotide polymorphism
(rs2230500 single-nucleotide polymorphism) in exon 9 of the protein kinase C eta (PRKCH) gene is an independent risk factor for ischemic stroke: stroke incidence is significantly
higher in the subjects with AA than those with AG or GG genotype. However, its impact
on stroke recurrence remains unknown. The aim of the present study was to clarify
whether the polymorphism is also a risk factor for recurrent stroke in patients with
acute ischemic stroke.
Methods
We enrolled 2418 consecutive patients with acute and first-ever ischemic stroke and
investigated the 1425G/A polymorphism of PRKCH. Patients were followed up for a median of 733 days. The association between the
polymorphism and stroke recurrence was investigated using the Cox proportional hazard
model.
Results
In the enrolled patients, the GG genotype was the most prevalent (63%), followed by
AG (32%) and AA genotypes (5%). Recurrent stroke occurred in 302 patients during the
follow-up period. Kaplan–Meier analyses revealed no difference in the rate of recurrent
stroke after first-ever stroke among the 3 genotypes. The incidence of recurrent stroke
was not significantly different in patients with AA (hazard ratio [HR] 1.02, 95% confidence
interval .59-1.64, P = .94) or AG (HR .89, 95% confidence interval .69-1.14, P = .36) genotypes compared with those with the GG genotype after adjusting for multiple
confounders.
Conclusions
The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic
stroke during a 2-year follow-up period.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Stroke and Cerebrovascular DiseasesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ten-year prognosis of stroke and risk factors for death in a Japanese community: the Hisayama study.Stroke. 2003; 34: 2343-2347
- Risk score for predicting recurrence in patients with ischemic stroke: the fukuoka stroke risk score for Japanese.Cerebrovasc Dis. 2012; 34: 351-357
- Unravelling the genetics of ischaemic stroke.PLoS Med. 2010; 7: e1000225
- The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.Nat Genet. 2003; 35: 131-138
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.Nat Genet. 2004; 36: 233-239
- A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.Nat Genet. 2007; 39: 212-217
- Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls.Neurosci Lett. 2012; 506: 55-58
- The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population.Stroke. 2009; 40: 2973-2976
- Proteinuria and clinical outcomes after ischemic stroke.Neurology. 2012; 78: 1909-1915
- Clinical significance of plasma VEGF value in ischemic stroke—research for biomarkers in ischemic stroke (REBIOS) study.BMC Neurol. 2013; 13: 32
- Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases III.Stroke. 1990; 21: 637-676
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke. 1993; 24: 35-41
- Cardiogenic brain embolism. Cerebral Embolism Task Force.Arch Neurol. 1986; 43: 71-84
- Contribution of 1425G/A polymorphism in protein kinase C-eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study.J Neurogenet. 2011; 25: 82-87
- Association between PRKCH gene polymorphisms and subcortical silent brain infarction.Atherosclerosis. 2008; 199: 340-345
- Association of PRKCH gene with lacunar infarction in a local Chinese Han population.Neurosci Lett. 2009; 464: 146-149
- Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan.J Biomed Sci. 2012; 19: 1
- Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population.Stroke. 2012; 43: 14-21
- Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.Nan Fang Yi Ke Da Xue Xue Bao. 2010; 30 (1895): 1890-1892
- C-reactive protein gene C1444T polymorphism and risk of recurrent ischemic events in patients with symptomatic intracranial atherostenoses.Cerebrovasc Dis. 2009; 28: 95-102
Article info
Publication history
Published online: February 19, 2014
Accepted:
November 13,
2013
Received in revised form:
November 11,
2013
Received:
October 15,
2013
Footnotes
R.M. and T.A. contributed equally to this study.
Sources of funding: This study was funded in part by a Grant-in-Aid for Scientific Research (A 22249069) and Co-ordination, Support, and Training Program for Translational Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology.
Disclosures: None.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.011
Copyright
© 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
