We estimated the stiffness parameter β (β value), which is useful in the assessment of premature atherosclerosis, among patients with different subtypes of cerebral infarction (CI; eg, small-vessel occlusion, large-artery atherosclerosis, cardioembolism, and other determined and undetermined etiologies) to determine the clinical utility of the β value in classification of stroke patients into CI subtypes.
Carotid ultrasonography (ALOKA ProSound SSD-alpha10) was performed in 31 CI patients and 38 control subjects, and the β value of the bilateral common carotid artery at 2.0 cm proximal to the bifurcation was measured using the echo-tracking method. The relationship between β value and age was examined, and the β value was compared among the different CI subtypes.
Positive β value correlated with age in control subjects (R = .69, P < .001) but not in CI patients (R = −.01, P = .996). There was no significant difference in the β value when comparing control patients and patients with cardioembolic stroke (P = .106), but the β value were lower in patients with cardioembolic stroke than in patients with noncardioembolic stroke (eg, small-vessel occlusion, large-artery atherosclerosis, and others, P = .009).
The β value was lower in patients with cardioembolic stroke than in patients with noncardioembolic stroke. The β value may be useful for estimating the risk of different stroke subtypes.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Stroke and Cerebrovascular Diseases
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States.Circulation. 2000; 102: 3137-3147
- Risk factors and outcome of subtypes of ischemic stroke. Data from a multicenter multinational hospital-based registry. The European Community Stroke Project.J Neurol Sci. 2006; 244: 143-150
- Alterations with age in the viscoelastic properties of human arterial walls.Circ Res. 1966; 18: 278-292
- Aortic stiffness is an independent predictor of fatal stroke in essential hypertension.Stroke. 2003; 34: 1203-1206
- Brachial-ankle pulse wave velocity and symptomatic cerebral infarction in patients with type 2 diabetes: a cross-sectional study.Cardiovasc Diabetol. 2003; 2: 10
- Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama study.Cerebrovasc Dis (Basel, Switzerland). 2011; 31: 329-337
- Reproducibility of arterial stiffness indices (pulse wave velocity and augmentation index) simultaneously assessed by automated pulse wave analysis and their associated risk factors in essential hypertensive patients.Hypertens Res. 2004; 27: 851-857
- Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries.Cardiovasc Res. 1987; 21: 678-687
- Stiffness and elastic behavior of human intracranial and extracranial arteries.J Biomechanics. 1980; 13: 175-184
- A new noninvasive measurement system for wave intensity: evaluation of carotid arterial wave intensity and reproducibility.Heart Vessels. 2002; 17: 12-21
- Relation of stiffness parameter beta to carotid arteriosclerosis and silent cerebral infarction in patients on chronic hemodialysis.Int Urol Nephrol. 2009; 41: 739-745
- Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients.Atherosclerosis. 2010; 210: 145-149
- The combination of IMT and stiffness parameter β is highly associated with concurrent coronary artery disease in type 2 diabetes.J Atheroscler Thromb. 2009; 16: 33-39
- Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis.Circulation. 1989; 80: 78-86
- Echo-tracking assessment of carotid artery stiffness in patients with aortic valve stenosis.Echocardiography. 2009; 26: 823-831
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Toast. Trial of Org 10172 in Acute Stroke Treatment.Stroke. 1993; 24: 35-41
- Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males—a pilot study.Atherosclerosis. 2011; 215: 446-451
- Plasma brain natriuretic peptide can be a biological marker to distinguish cardioembolic stroke from other stroke types in acute ischemic stroke.Int Med. 2009; 48: 259-264
- Association between arterial stiffness and atherosclerosis: The Rotterdam Study.Stroke. 2001; 32: 454-460
Published online: January 06, 2014
Accepted: November 20, 2013
Received in revised form: November 14, 2013
Received: August 29, 2013
H.F. passed away in 2012.
© 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.