Background
There is an increasing interest in the role of inflammatory mechanisms contributing
to the development of stroke. Recent studies have reported an association between
allele 2 of a variable number tandem repeat of the interleukin-1 receptor antagonist (IL1RN) gene in Caucasian patients with ischemic stroke. The purpose of this investigation
is to independently confirm these results in our study population.
Methods
We recruited and genotyped 516 Caucasian patients with ischemic stroke and 380 matched
controls. Tests of association were performed to estimate odds ratio (OR) for the
IL1RN gene variable number tandem repeat polymorphism with case–control status. Genotype
frequencies of IL1RN gene were compared by case–control and symptom status using χ2 contingency tables and logistic regression models.
Results
No significant association was observed between any of the IL1RN gene genotypes and ischemic stroke. The unadjusted association model a, and the fully
saturated model e, adjusted for age, gender, and stroke risk factors demonstrated
no significant increase in risk associated with the IL1RN gene 2/2 genotype (a: OR, 1.11; 95% confidence interval [CI], .67-1.89; P = .615; and e: OR, .95; 95% CI, .46-1.94; P = .574). Analyses of genotypic and allelic frequencies of each Trial of Org 10172
in Acute Stroke Treatment subtype with control and pairwise comparison between stroke
subtypes did not show any significant differences in their distributions, and all
P values were greater than the significance level of .05.
Conclusion
Our results do not confirm an association between the gene and ischemic stroke in
Caucasian patients.
Key Words
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Article info
Publication history
Published online: March 28, 2014
Accepted:
December 29,
2013
Received:
September 19,
2013
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.045
Copyright
© 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
