Advertisement
Original Article| Volume 24, ISSUE 8, P1738-1748, August 2015

Task-Based Mirror Therapy Augmenting Motor Recovery in Poststroke Hemiparesis: A Randomized Controlled Trial

      Background

      To establish the effect of the task-based mirror therapy (TBMT) on the upper limb recovery in stroke.

      Methods

      A pilot, randomized, controlled, assessor-blinded trial was conducted in a rehabilitation institute. A convenience sample of 33 poststroke (mean duration, 12.5 months) hemiparetic subjects was randomized into 2 groups (experimental, 17; control, 16). The subjects were allocated to receive either TBMT or standard motor rehabilitation—40 sessions (5/week) for a period of 8 weeks. The TBMT group received movements using various goal-directed tasks and a mirror box. The movements were performed by the less-affected side superimposed on the affected side. The main outcome measures were Brunnstrom recovery stage (BRS) and Fugl-Meyer assessment (FMA)—FMA of upper extremity (FMA-UE), including upper arm (FMA-UA) and wrist–hand (FMA-WH).

      Results

      The TBMT group exhibited highly significant improvement on mean scores of FMA-WH (P < .001) and FMA-UE (P < .001) at postassessment in comparison to the control group. Furthermore, there was a 12% increase in the number of subjects at BRS stage 5 (out of synergy movement) in the experimental group as compared to a 0% rise at the same stage in the control group.

      Conclusions

      This pilot trial confirmed the role of TBMT in improving the wrist–hand motor recovery in poststroke hemiparesis. MT using tasks may be used as an adjunct in stroke rehabilitation.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Stroke and Cerebrovascular Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Selles R.W.
        • Michielsen M.E.
        • Bussmann J.B.
        • et al.
        Effects of a mirror-induced visual illusion on a reaching task in stroke patients: implications for mirror therapy training.
        Neurorehabil Neural Repair. 2014; 28: 652-659
        • Wu C.Y.
        • Huang P.C.
        • Chen Y.T.
        • et al.
        Effects of mirror therapy on motor and sensory recovery in chronic stroke: a randomized controlled trial.
        Arch Phys Med Rehabil. 2013; 94: 1023-1030
        • Bhasin A.
        • Padma Srivastava M.V.
        • Kumaran S.S.
        • et al.
        Neural interface of mirror therapy in chronic stroke patients: a functional magnetic resonance imaging study.
        Neurol India. 2012; 60: 570-576
        • Lee M.M.
        • Cho H.Y.
        • Song C.H.
        The mirror therapy program enhances upper-limb motor recovery and motor function in acute stroke patients.
        Am J Phys Med Rehabil. 2012; 91: 689-696
        • Ertelt D.
        • Hemmelmann C.
        • Dettmers C.
        • et al.
        Observation and execution of upper-limb movements as a tool for rehabilitation of motor deficits in paretic stroke patients: protocol of a randomized clinical trial.
        BMC Neurol. 2012; 12: 42
        • Carvalho D.
        • Teixeira S.
        • Lucas M.
        • et al.
        The mirror neuron system in post-stroke rehabilitation.
        Int Arch Med. 2013; 6: 41
        • Fritzsch C.
        • Wang J.
        • Dos Santos L.F.
        • et al.
        Different effects of the mirror illusion on motor and somatosensory processing.
        Restor Neurol Neurosci. 2014; 32: 269-280
        • Avanzino L.
        • Raffo A.
        • Pelosin E.
        • et al.
        Training based on mirror visual feedback influences transcallosal communication.
        Eur J Neurosci. 2014; 13: 12615
        • Cattaneo L.
        • Rizzolatti G.
        The mirror neuron system.
        Arch Neurol. 2009; 66: 557-560
        • Garrison K.A.
        • Winstein C.J.
        • Aziz-Zadeh L.
        The mirror neuron system: a neural substrate for methods in stroke rehabilitation.
        Neurorehabil Neural Repair. 2010; 24: 404-412
        • Sale P.
        • Franceschini M.
        Action observation and mirror neuron network: a tool for motor stroke rehabilitation.
        Eur J Phys Rehabil Med. 2012; 48: 313-318
        • Priganc V.W.
        • Stralka S.W.
        Graded motor imagery.
        J Hand Ther. 2011; 24: 164-168
        • Arya K.N.
        • Pandian S.
        Effect of task-based mirror therapy on motor recovery of the upper extremity in chronic stroke patients: a pilot study.
        Top Stroke Rehabil. 2013; 20: 210-217
        • Dohle C.
        • Pullen J.
        • Nakaten A.
        • et al.
        Mirror therapy promotes recovery from severe hemiparesis: a randomized controlled trial.
        Neurorehabil Neural Repair. 2009; 23: 209-217
        • Michielsen M.E.
        • Selles R.W.
        • van der Geest J.N.
        • et al.
        Motor recovery and cortical reorganization after mirror therapy in chronic stroke patients: a phase II randomized controlled trial.
        Neurorehabil Neural Repair. 2011; 25: 223-233
        • Sutbeyaz S.
        • Yavuzer G.
        • Sezer N.
        • et al.
        Mirror therapy enhances lower-extremity motor recovery and motor functioning after stroke: a randomized controlled trial.
        Arch Phys Med Rehabil. 2007; 88: 555-559
        • Thieme H.
        • Mehrholz J.
        • Pohl M.
        • et al.
        Mirror therapy for improving motor function after stroke.
        Cochrane Database Syst Rev. 2012; 3: CD008449
        • Villiger M.
        • Chandrasekharan S.
        • Welsh T.N.
        Activity of human motor system during action observation is modulated by object presence.
        Exp Brain Res. 2011; 209: 85-93
        • Veerbeek J.M.
        • van Wegen E.
        • van Peppen R.
        • et al.
        What is the evidence for physical therapy poststroke? A systematic review and meta-analysis.
        PLoS One. 2014; 9: e87987
        • Arya K.N.
        • Verma R.
        • Garg R.K.
        • et al.
        Meaningful task-specific training (MTST) for stroke rehabilitation: a randomized controlled trial.
        Top Stroke Rehabil. 2012; 19: 193-211
        • Rensink M.
        • Schuurmans M.
        • Lindeman E.
        • et al.
        Task-oriented training in rehabilitation after stroke: systematic review.
        J Adv Nurs. 2009; 65: 737-754
        • Bayona N.A.
        • Bitensky J.
        • Salter K.
        • et al.
        The role of task-specific training in rehabilitation therapies.
        Top Stroke Rehabil. 2005; 12: 58-65
        • Agnew Z.K.
        • Wise R.J.
        • Leech R.
        Dissociating object directed and non-object directed action in the human mirror system; implications for theories of motor simulation.
        PLoS One. 2012; 7: e32517
        • Donnan G.A.
        • Fisher M.
        • Macleod M.
        • et al.
        Stroke.
        Lancet. 2008; 371: 1612-1623
        • Pandian S.
        • Arya K.
        Relation between the upper extremity synergistic movement components and its implication for motor recovery in post-stroke patients.
        Top Stroke Rehabil. 2012; 19: 545-555
        • Brott T.
        • Adams Jr., H.P.
        • Olinger C.P.
        • et al.
        Measurements of acute cerebral infarction: a clinical examination scale.
        Stroke. 1989; 20: 864-870
        • Bobath B.
        Adult hemiplegia: evaluation and treatment.
        3rd ed. Butterworth- Heinemann, New Delhi1990
        • Pedleton H.M.
        • Schultz-Krohn W.
        Pedretti's Occupational Therapy: Practice Skills for Physical Dysfunction.
        7th ed. Elsevier Mosby, Missouri2013
        • Sawner K.
        • Jeanne L.
        Brunnstrom movement therapy in hemiplegia: a neurophysilogical approach.
        2nd ed. JB Lippincott, Philadelphia1992
        • Safaz I.
        • Yilmaz B.
        • Yasar E.
        • et al.
        Brunnstrom recovery stage and motricity index for the evaluation of upper extremity in stroke: analysis for correlation and responsiveness.
        Int J Rehabil Res. 2009; 32: 228-231
        • Naghdi S.
        • Ansari N.N.
        • Mansouri K.
        • et al.
        A neurophysiological and clinical study of Brunnstrom recovery stages in the upper limb following stroke.
        Brain Inj. 2010; 24: 1372-1378
        • Hashimoto K.
        • Higuchi K.
        • Nakayama Y.
        • et al.
        Ability for basic movement as an early predictor of functioning related to activities of daily living in stroke patients.
        Neurorehabil Neural Repair. 2007; 21: 353-357
        • Fugl-Meyer A.R.
        • Jaasko L.
        • Leyman I.
        • et al.
        The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance.
        Scand J Rehabil Med. 1975; 7: 13-31
        • Duncan P.W.
        • Propst M.
        • Nelson S.G.
        Reliability of the Fugl-Meyer assessment of sensorimotor recovery following cerebrovascular accident.
        Phys Ther. 1983; 63: 1606-1610
        • Gladstone D.J.
        • Danells C.J.
        • Black S.E.
        The Fugl-Meyer assessment of motor recovery after stroke: a critical review of its measurement properties.
        Neurorehabil Neural Repair. 2002; 16: 232-240
        • Sanford J.
        • Moreland J.
        • Swanson L.R.
        • et al.
        Reliability of the Fugl-Meyer assessment for testing motor performance in patients following stroke.
        Phys Ther. 1993; 73: 447-454
        • Page S.J.
        • Levine P.
        • Hade E.
        Psychometric properties and administration of the wrist/hand subscales of the Fugl-Meyer assessment in minimally impaired upper extremity hemiparesis in stroke.
        Arch Phys Med Rehabil. 2012; 93: 2373-2376
        • Hiengkaew V.
        • Jitaree K.
        • Chaiyawat P.
        Minimal detectable changes of the Berg Balance Scale, Fugl-Meyer Assessment Scale, Timed “Up & Go” Test, gait speeds, and 2-minute walk test in individuals with chronic stroke with different degrees of ankle plantarflexor tone.
        Arch Phys Med Rehabil. 2012; 93: 1201-1208
        • Vickers A.J.
        • Altman D.G.
        Statistics notes: analysing controlled trials with baseline and follow up measurements.
        BMJ. 2001; 323: 1123-1124
        • Yavuzer G.
        • Selles R.
        • Sezer N.
        • et al.
        Mirror therapy improves hand function in subacute stroke: a randomized controlled trial.
        Arch Phys Med Rehabil. 2008; 89: 393-398
        • Alexander C.
        • Miley R.
        • Stynes S.
        • et al.
        Differential control of the scapulothoracic muscles in humans.
        J Physiol. 2007; 580: 777-786
        • Bawa P.
        • Hamm J.D.
        • Dhillon P.
        • et al.
        Bilateral responses of upper limb muscles to transcranial magnetic stimulation in human subjects.
        Exp Brain Res. 2004; 158: 385-390
        • Garry M.I.
        • Loftus A.
        • Summers J.J.
        Mirror, mirror on the wall: viewing a mirror reflection of unilateral hand movements facilitates ipsilateral m1 excitability.
        Exp Brain Res. 2005; 163: 118-122
        • Wang J.
        • Fritzsch C.
        • Bernarding J.
        • et al.
        Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects.
        NeuroRehabilitation. 2013; 33: 593-603
        • Arya K.N.
        • Verma R.
        • Garg R.K.
        Estimating the minimal clinically important difference of an upper extremity recovery measure in subacute stroke patients.
        Top Stroke Rehabil. 2011; 18: 599-610
        • Invernizzi M.
        • Negrini S.
        • Carda S.
        • et al.
        The value of adding mirror therapy for upper limb motor recovery of subacute stroke patients: a randomized controlled trial.
        Eur J Phys Rehabil Med. 2013; 49: 311-317
        • Hubbard I.J.
        • Parsons M.W.
        • Neilson C.
        • et al.
        Task-specific training: evidence for and translation to clinical practice.
        Occup Ther Int. 2009; 16: 175-189
        • Hamzei F.
        • Lappchen C.H.
        • Glauche V.
        • et al.
        Functional plasticity induced by mirror training: the mirror as the element connecting both hands to one hemisphere.
        Neurorehabil Neural Repair. 2012; 26: 484-496
        • Seo N.J.
        Involuntary contralateral upper extremity muscle activation pattern during unilateral pinch grip following stroke.
        J Hand Ther. 2013; 26: 272-277
        • Romano D.
        • Bottini G.
        • Maravita A.
        Perceptual effects of the mirror box training in normal subjects.
        Restor Neurol Neurosci. 2013; 31: 373-386
        • Small S.L.
        • Buccino G.
        • Solodkin A.
        The mirror neuron system and treatment of stroke.
        Dev Psychobiol. 2012; 54: 293-310
        • Franceschini M.
        • Agosti M.
        • Cantagallo A.
        • et al.
        Mirror neurons: action observation treatment as a tool in stroke rehabilitation.
        Eur J Phys Rehabil Med. 2010; 46: 517-523
        • Rizzolatti G.
        • Fogassi L.
        The mirror mechanism: recent findings and perspectives.
        Philos Trans R Soc Lond B Biol Sci. 2014; 369 (20130420)
        • Buccino G.
        Action observation treatment: a novel tool in neurorehabilitation.
        Philos Trans R Soc Lond B Biol Sci. 2014; 369 (20130185)
        • Roberts P.S.
        • Vegher J.A.
        • Gilewski M.
        • et al.
        Client-centered occupational therapy using constraint-induced therapy.
        J Stroke Cerebrovasc Dis. 2005; 14: 115-121
        • Govender P.
        • Kalra L.
        Benefits of occupational therapy in stroke rehabilitation.
        Expert Rev Neurother. 2007; 7: 1013-1019
        • Teasell R.
        • Mehta S.
        • Pereira S.
        • et al.
        Time to rethink long-term rehabilitation management of stroke patients.
        Top Stroke Rehabil. 2012; 19: 457-462
        • Ganguli M.
        • Ratcliff G.
        • Chandra V.
        • et al.
        A hindi version of the MMSE: the development of a cognitive screening instrument for a largely illiterate rural elderly population in India.
        Int J Geriatr Psychiatry. 1995; 10: 367-377