Background
Improving cerebral perfusion remains a good option for ischemic stroke for restoring
cerebral blood flow. Human urinary kallidinogenase has been shown promising in treating
stroke patients. To investigate whether human urinary kallidinogenase's efficacy in
treating stroke patients has relationship with improving cerebral perfusion and possible
mechanism.
Methods
Fifty-eight stroke patients in Nanjing Drum Tower Hospital were enrolled in this prospective
study. Of them, 29 received human urinary kallidinogenase, while the other 29 were
selected as control. National institute health stroke scale, modified Rankin Scale
and activities of daily living score were used to determine patient outcome. Cerebral
perfusion in patients was determined by perfusion magnetic resonance imaging. Serum
apelin and vascular endothelial growth factor were measured by enzyme-linked immunosorbent
assay.
Results
We confirmed that human urinary kallidinogenase improved stroke outcome in patients.
Cerebral perfusion was elevated by human urinary kallidinogenase 12 days after therapy.
Human urinary kallidinogenase enhanced vascular endothelial growth factor and APJ
expression in stroke patients. The reduced mean transit time was related with favorable
outcome analyzed by univariate logistic regression.
Conclusions
Human urinary kallidinogenase facilitated stroke recovery and enhanced cerebral reperfusion
through up-regulating vascular endothelial growth factor, apelin/APJ pathway.
Key Words
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Article info
Publication history
Published online: June 29, 2015
Accepted:
March 17,
2015
Received in revised form:
March 11,
2015
Received:
January 27,
2015
Footnotes
J.L., Y.C., and X.Z. contributed to the work equally.
This study was supported by the National Natural Science Foundation of China (81200896, 81230026, 81171085, 81200897), Outstanding Researcher Program (LJ 201101) of Jiangsu Province, and the National Natural Science Foundation (BK2009037) of Jiangsu Province of China.
The authors declare that they have no conflicts of interest.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.032
Copyright
© 2015 Published by Elsevier Inc.
