Background
The DRAGON score predicts functional outcome of ischemic stroke patients treated with
intravenous thrombolysis. Our aim was to evaluate its utility in a Chinese stroke
population.
Methods
Patients with acute ischemic stroke treated with intravenous thrombolysis were prospectively
registered in the Thrombolysis Implementation and Monitor of acute ischemic Stroke
in China. We excluded patients with basilar artery occlusion and missing data, leaving
970 eligible patients. We calculated the DRAGON score, and the clinical outcome was
measured by the modified Rankin Scale at 3 months. Model discrimination was quantified
by calculating the C statistic. Calibration was assessed using Pearson correlation
coefficient.
Results
The C statistic was .73 (.70-.76) for good outcome and .75 (.70-.79) for miserable
outcome. Proportions of patients with good outcome were 94%, 83%, 70%, and 0% for
0 to 1, 2, 3, and 8 to 10 score points, respectively. Proportions of patients with
miserable outcome were 0%, 3%, 9%, and 50% for 0 to 1, 2, 3, and 8 to 10 points, respectively.
There was high correlation between predicted and observed probability of 3-month favorable
and miserable outcome in the external validation cohort (Pearson correlation coefficient,
.98 and .98, respectively, both P < .0001).
Conclusions
The DRAGON score showed good performance to predict functional outcome after tissue-type
plasminogen activator treatment in the Chinese population. This study demonstrated
the accuracy and usability of the DRAGON score in the Chinese population in daily
practice.
Key Words
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Article info
Publication history
Published online: May 28, 2015
Accepted:
March 18,
2015
Received in revised form:
January 16,
2015
Received:
October 23,
2014
Footnotes
The authors did not receive any grant support.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.046
Copyright
© 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.
