Background
There have been no prospective studies on the clinical features, etiologies, and outcome
of transient ischemic attack (TIA) in Korea. The aim of this study was to identify
variables that can discriminate TIA from TIA mimics. Also we evaluated the characteristic
of TIA patients according to the presence of diffusion-weighted imaging (DWI) lesion.
Methods
Patients were categorized into TIA and TIA mimics according to the result of an initial
workup. TIA patients were divided according to the presence of DWI lesions. Baseline
demographics, risk factors, laboratory results, initial blood pressure, imaging findings,
recurrence rate of TIA or stroke at 3 months, and initial neurologic manifestations
were prospectively collected and compared.
Results
We evaluated a total of 252 patients (212 with TIA and 40 with TIA mimics). Steno-occlusion
of the relevant artery (odds ratio [OR], 22.39; 95% confidence interval [CI], 2.03-246.73)
and cardioembolic risk (OR, 32.15; 95% CI, 1.12-922.97) were significantly associated
with TIA. Amnesia (OR, .001; 95% CI, .00-.05) and consciousness disturbance (OR, .003;
95% CI, .00-.06) favored TIA mimics. Perfusion defect (OR, 5.56; 95% CI, 2.90-10.68)
and cardioembolic risk (OR, 2.68; 95% CI, 1.14-6.32) were significantly associated
with DWI lesion. Recurrence did not significantly differ according to the presence
of a lesion on DWI (positive, 4.9%; negative, 7.8%; P = .41).
Conclusion
Steno-occlusive disease and cardioembolic risk were independently associated with
TIA. Perfusion defect and cardioembolic risk predicted positive DWI lesion. The value
of various imaging modalities for predicting TIA etiology needs further evaluation.
Key Words
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Article info
Publication history
Published online: June 29, 2015
Accepted:
April 3,
2015
Received in revised form:
April 1,
2015
Received:
November 27,
2014
Footnotes
The authors declare that they have no conflicts of interest.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.04.007
Copyright
© 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.
