Background
This study investigated the contribution of deep cerebral microbleeds (MBs) to stroke
recurrences in patients with histories of deep intracerebral hemorrhages (ICHs) or
lacunar infarctions (LIs).
Methods
We prospectively analyzed stroke recurrences in patients admitted to our hospital
who were treated for deep ICHs or LIs between April 2004 and December 2011. The number
of deep MBs was counted on admission. Stroke recurrence–free rate curves were generated
with the Kaplan–Meier method using the log-rank test. The odds ratios (ORs) for recurrent
strokes were derived using multivariate logistic regression models, based on deep
MBs and risk factors.
Results
We evaluated magnetic resonance images or the recurrences of 231 deep-ICH patients
(92 women, 68.0 ± 12.0 years old) and 309 LI patients (140 women, 70.7 ± 11.7 years
old). The incidences of deep ICHs (1.5%/year) and LIs (2.1%/year) presenting as stroke
recurrences were significantly larger in LI patients with deep MBs than in those without
(.01 [P = .0001] and .08%/year [P = .005], respectively). However, there was no significant difference between deep-ICH
patients with and without MBs in terms of incidence of recurrences. Multivariate analyses
revealed that deep MBs independently and significantly elevated the rate of deep ICHs
(OR, 19.0; P = .007) or LIs (OR, 3.62; P = .008) presenting as recurrences in LI patients, but not in deep-ICH patients, when
adjusted for stroke risk factors.
Conclusions
There may be differences between patients with deep ICHs and those with LIs in terms
of the contribution of deep MBs to stroke recurrence.
Key Words
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Article info
Publication history
Published online: May 14, 2015
Accepted:
April 17,
2015
Received in revised form:
April 9,
2015
Received:
November 6,
2014
Footnotes
The authors declare that they have no financial conflicts of interest and they did not receive any grants.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.04.027
Copyright
© 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.
