Background
Although recent studies have shown that the elevation of serum triglyceride (TG) is
related to the increased incidence of ischemic stroke, the relationship between hypertriglyceridemia
and subtypes of ischemic stroke is largely unknown. This study attempted to evaluate
whether hypertriglyceridemia is associated with lacunar stroke in diabetes mellitus
(DM).
Methods
A total of 2141 consecutive patients with acute ischemic stroke were enrolled from
March 2005 to April 2014, excluding the subjects with undetermined/other determined
etiology or no lipid data. We compared the lipid profiles among stroke subtypes. The
estimated serum TG levels and the interaction between DM and stroke subtypes were
determined by analysis of covariance (ANCOVA) and Tukey's multiple comparison.
Results
In ANCOVA test, the difference of estimated TG between DM and non-DM patients was
largest in small-vessel occlusion (SVO; 159.7 [95% confidence interval {CI}, 143.2-176.2]
versus 122.4 [95% CI, 106.1-138.7]), and a significant interaction was observed between
DM and stroke subtypes for TG levels (P = .013) but not for total cholesterol (P = .363), low-density lipoprotein cholesterol (P = .171), or high-density lipoprotein cholesterol (P = .231). By Tukey's multiple comparison, SVO was consistently associated with DM
for serum TG levels (P < .001).
Conclusions
In acute ischemic stroke with DM, serum TG level was significantly associated with
lacunar infarction adjusting for other lipid profiles and vascular risk factors. Further
studies are warranted to reveal the pathophysiologic implication of hypertriglyceridemia
for lacunar infarction in type 2 DM.
Key Words
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Article info
Publication history
Published online: May 21, 2015
Accepted:
April 21,
2015
Received in revised form:
April 16,
2015
Received:
March 9,
2015
Footnotes
This study was supported by the (1) Soonchunhyang University Research Fund and (2) a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020).
The authors declare that they have no conflicts of interest.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.04.030
Copyright
© 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.
