Background
Currently, the most effective treatment for brain ischemic stroke is recombinant tissue
plasminogen activator (rt-PA); however, increased incidence of symptomatic intracerebral
hemorrhage severely reduced its favorable treatment outcome.
Methods
We aimed to investigate the effect of ginsenoside (Gs) on symptomatic intracerebral
hemorrhage after rt-PA treatment. Stroke patients were randomly divided into 2 treatment
groups, one receiving rt-PA + placebo (Pc) and the other rt-PA + Gs. Twenty-four hours
after the treatment, outcomes were assessed with transcranial Doppler (TCD) ultrasonography
and National Institutes of Health Stroke Scale (NIHSS), and plasma levels of transforming
growth factor-β1 (TGF-β1), matrix metalloproteinase (MMP)-2, and MMP-9 were also measured.
After initial cotreatment, the patients were continuously administered with either
Pc or Gs, and the treatment outcomes at 7 days were assessed with TCD, NIHSS, modified
Rankin scale (MRS), and Glasgow outcome scale (GOS).
Results
Cotreatment of rt-PA with Gs significantly improved outcomes in patients compared
to the Pc group, as indicated by improved TCD and NIHSS scores and reduced incidence
of symptomatic intracerebral hemorrhage, which could be attributed to a Gs-induced
increase in TGF-β1 and a decrease in both MMP-2 and MMP-9 serum levels. Seven days
of Gs treatment also significantly improved outcomes in patients compared to the Pc
group, assessed by TCD, NIHSS, MRS, and GOS.
Conclusion
Our study supports the clinical use of Gs as a potential supplement with rt-PA treatment,
which reduces symptomatic intracerebral hemorrhage, therefore improving the treatment
outcome of stroke patients.
Key Words
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Article info
Publication history
Published online: December 09, 2015
Accepted:
November 3,
2015
Received in revised form:
October 19,
2015
Received:
September 2,
2015
Footnotes
Grant support: This work was supported by the Youth Excellent Talents Training Program of Pudong Health Bureau of Shanghai (Grant No. PWRq2013-06).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.004
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
