Background
Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD),
a definite relationship between them has not been established. This study assessed
whether low estimated glomerular filtration is associated with risk of different subtypes
of CSVDs.
Methods
Electronic databases were systematically searched for studies reporting an odds ratio
of the association between low estimated glomerular filtration and CSVD risk. Sixteen
studies, including 10,534 participants, were identified. A fix effects model was applied
and odds ratios (ORs) with 95% confidence intervals were presented.
Results
Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration
(OR = 2.20). Stratified analyses consistently showed significant associations across
different subtypes, with pooled OR being greatest in subjects with silent cerebral
infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate
of studies showing OR as a continuous variable showed results consistent with the
former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular
filtration.
Conclusions
This study revealed that low estimated glomerular filtration was significantly associated
with risk of CSVDs. Low estimated glomerular filtration was most strongly associated
with SCI (OR = 2.71) among subtypes of CSVDs.
Key Words
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Article info
Publication history
Published online: January 08, 2016
Accepted:
November 7,
2015
Received in revised form:
November 3,
2015
Received:
October 15,
2015
Footnotes
This study was funded by Grant 2012ZX09303-005-003 from the National S&T Major Project of China.
Authors' contributions: Yuanyuan Liu, Lemin Zheng, and Yining Huang designed the study, analyzed and interpreted the results, and drafted the manuscript. Haiqiang Jin and Pu Lv acquired the data. Yuanyuan Liu, Wei Cui, Chenguang Niu, Mingming Zhao, Chenghe Fan, Yuming Teng, Qing Peng, and Jingjing Luo analyzed and interpreted the data. All authors participated in discussions and interpretation of results and all approved the final version of the manuscript for submission.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.016
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
