Background
Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular
events. The aim of this study was to estimate rates of recurrent stroke, myocardial
infarction (MI), and major vascular events during the first year after AIS in Korea.
Methods
Through a multicenter stroke registry in Korea, 12,227 consecutive cases of AIS were
identified between November 2010 and May 2013 and were followed up for recurrent stroke,
MI, and major vascular events up to 1 year after stroke.
Results
Cumulative 30-day, 90-day and 1-year rates were 2.7%, 3.9%, and 5.7% for recurrent
stroke; .1%, .3%, and .5% for MI; and 8.1%, 10.6%, and 13.7% for major vascular events,
indicating that the early period is at high risk of recurrent stroke and major vascular
events. The risk of recurrent stroke was substantially higher than the risk of MI:
13.0 times at 90 days and 11.4 times at 1 year. Compared to those with small-vessel
occlusion (SVO), those with ischemic stroke subtypes other than SVO had a higher risk
of recurrent stroke as well as major vascular events. Other common independent predictors
for recurrent stroke and major vascular events were diabetes and prior stroke history.
Conclusions
During the first year after AIS, one in 18 had recurrent stroke and one in 7 major
vascular events. More than two thirds of recurrent stroke and three quarters of major
vascular events developed within 90 days in a Korean cohort of stroke patients. Better
prevention strategies are required for high-risk patients during this high-risk period.
Key Words
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Article info
Publication history
Published online: December 29, 2015
Accepted:
November 23,
2015
Received in revised form:
November 19,
2015
Received:
September 21,
2015
Footnotes
Grant support: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020) and by a grant from Korea Otsuka Pharmaceuticals.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.036
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
