Background
Brain edema formation is a major cause of brain damages and the high mortality of
ischemic stroke. The aim of this review is to explore the relationship between ischemic
brain edema formation and vasopressin (VP) hypersecretion in addition to the oxygen
and glucose deprivation and the ensuing reperfusion injury.
Methods
Pertinent studies involving ischemic stroke, brain edema formation, astrocytes, and
VP were identified by a search of the PubMed and the Web of Science databases in January
2016. Based on clinical findings and reports of animal experiments using ischemic
stroke models, this systematic review reanalyzes the implication of individual reports
in the edema formation and then establishes the inherent links among them.
Results
This systematic review reveals that cytotoxic edema and vasogenic brain edema in classical
view are mainly under the influence of a continuous malfunction of astrocytic plasticity.
Adaptive VP secretion can modulate membrane ion transport, water permeability, and
blood–brain barrier integrity, which are largely via changing astrocytic plasticity.
Maladaptive VP hypersecretion leads to disruptions of ion and water balance across
cell membranes as well as the integrity of the blood–brain barrier. This review highlights
our current understandings of the cellular mechanisms underlying ischemic brain edema
formation and its association with VP hypersecretion.
Conclusions
VP hypersecretion promotes brain edema formation in ischemic stroke by disrupting
hydromineral balance in the neurovascular unit; suppressing VP hypersecretion has
the potential to alleviate ischemic brain edema.
Key Words
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Article info
Publication history
Published online: April 05, 2016
Accepted:
February 1,
2016
Received in revised form:
January 21,
2016
Received:
December 14,
2015
Footnotes
This work is sponsored by the National Natural Science Foundation of China (Grant No. 31471113) and the Higher Education Talents Funds of Heilongjiang Province (Grant No. 002000154).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.02.002
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
