Background
We performed a meta-analysis aiming to clarify the relationship between monounsaturated
fatty acid (MUFA) intake and stroke risk.
Methods
Relevant studies were identified by searching relevant databases through January 2016.
We included cohort studies that reported relative risks (RRs) with 95% confidence
intervals (CIs) for the association between MUFA intake and stroke risk. A random-effects
model was used to derive composite RR estimates for stroke.
Results
Ten prospective cohort studies including 314,511 nonoverlapping individuals and 5827
strokes were included. Higher MUFA intake was not associated with risk of overall
stroke (RR = .86 [95% CI, .74-1.00]) and risk of ischemic stroke (RR = .92 [95% CI,
.79-1.08]), but was associated with a reduced risk of hemorrhagic stroke (RR = .68
[95% CI, .49-.96]). In subgroup analyses, higher MUFA intake was associated with a
reduced risk of stroke for a follow-up duration of 14 years or more (RR = .77 [95%
CI, .68-.87]), for males (RR = .79 [95% CI, .69-.91]), for 24-hour recall (RR = .74
[95% CI, .63-.86]), and for a quality score of more than 8 stars (RR = .78 [95% CI,
.61-.98]).
Conclusions
There is no significant evidence for concluding that dietary MUFA is associated with
a reduced risk of overall stroke. However, higher MUFA intake seems to be associated
with a reduced risk of hem orrhagic stroke but not ischemic stroke. Duration of MUFA
intake and sex are considered as factors affecting the relationship between MUFA intake
and stroke risk. Further studies are needed to evaluate the relationship between specific
food sources of MUFA (i.e., plant versus animal) and stroke risk.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Stroke and Cerebrovascular DiseasesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The global stroke initiative.Lancet Neurol. 2004; 3: 391-393
- Stroke, disability, and dementia results of a population survey.Stroke. 1997; 28: 531-536
- Relationships between long-term stroke disability, handicap and health-related quality of life.Age Ageing. 2006; 35: 273-279
- Monounsaturated fatty acids and risk of cardiovascular disease.Circulation. 1999; 100: 1253-1258
- Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart Randomized Trial.JAMA. 2005; 294: 2455-2464
- Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence.Public Health Nutr. 2006; 9: 251-257
- Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins—the Jerusalem Nutrition Study. II. Monounsaturated fatty acids vs carbohydrates.Am J Clin Nutr. 1992; 56: 394-403
- Effect of dietary monounsaturated fatty acids on plasma lipoproteins and apolipoproteins in women.Am J Clin Nutr. 1992; 56: 77-83
- High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations.Am J Clin Nutr. 1999; 70: 1009-1015
- Inverse association of dietary fat with development of ischemic stroke in men.JAMA. 1997; 278: 2145-2150
- Dietary lipids and incidence of cerebral infarction in a Japanese rural community.J Nutr Sci Vitaminol (Tokyo). 1997; 43: 83-99
- Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women.Circulation. 2001; 103: 856-863
- Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study.BMJ. 2003; 327: 777-782
- Fat and protein intakes and risk of intraparenchymal hemorrhage among middle-aged Japanese.Am J Epidemiol. 2003; 157: 32-39
- Animal protein, animal fat, and cholesterol intakes and risk of cerebral infarction mortality in the adult health study.Stroke. 2004; 35: 1531-1537
- Cardiovascular event risk in relation to dietary fat intake in middle-aged individuals: data from The Malmö Diet and Cancer Study.Eur J Cardiovasc Prev Rehabil. 2007; 14: 701-706
- Dietary fats and dietary cholesterol and risk of stroke in women.Atherosclerosis. 2012; 221: 282-286
- Relation of the traditional Mediterranean diet to cerebrovascular disease in a Mediterranean population.Am J Epidemiol. 2012; 176: 1185-1192
- Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the Malmo Diet and Cancer Cohort: a prospective study.PLoS ONE. 2012; 7: e31637
- Trans fat, aspirin, and ischemic stroke in postmenopausal women.Ann Neurol. 2012; 72: 704-715
- Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies.Lipids Health Dis. 2014; 13: 154
- Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.Eur J Epidemiol. 2010; 25: 603-605
- Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis.Ann Intern Med. 2014; 160: 398-406
- Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997; 315: 629-634
- Hypertension as a risk factor for spontaneous intracerebral hemorrhage.Stroke. 1986; 17: 1078-1083
- Effect of untreated hypertension on hemorrhagic stroke.Stroke. 2004; 35: 1703-1708
- Probability of stroke: a risk profile from the Framingham Study.Stroke. 1991; 22: 312-318
- Cigarette smoking as a risk factor for stroke: the Framingham Study.JAMA. 1988; 259: 1025-1029
- Meta-analysis of relation between cigarette smoking and stroke.BMJ. 1989; 298: 789
- Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: results from the 24-h dietary recalls.Eur J Clin Nutr. 2009; 63: S61-S80
- Heme iron intake and risk of stroke a prospective study of men.Stroke. 2013; 44: 334-339
- Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial.Atherosclerosis. 2005; 181: 149-158
- Free radical-scavenging properties of olive oil polyphenols.Biochem Biophys Res Commun. 1998; 247: 60-64
- The influence of olive oil on human health: not a question of fat alone.Mol Nutr Food Res. 2007; 51: 1199-1208
- Lipid peroxidation and its role in atherosclerosis.Br Med Bull. 1993; 49: 566-576
- Thematic review series: the pathogenesis of atherosclerosis the oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.J Lipid Res. 2004; 45: 993-1007
- Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case–control, cohort and intervention studies.Br J Nutr. 2014; 112: 248-259
- BMI affects the relationship between long chain N-3 polyunsaturated fatty acid intake and stroke risk: a meta-analysis.Sci Rep. 2015; 5: 14161
- Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies.BMJ. 2014; 349: g4490
Article info
Publication history
Published online: March 14, 2016
Accepted:
February 11,
2016
Received in revised form:
January 25,
2016
Received:
November 16,
2015
Footnotes
This study was supported by the National Natural Science Foundation of China (grant no. 81171113).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.02.017
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
