Background
The incidence of ischemic stroke in young adults has been rising over recent decades,
but there is still limited information on its risk factors, etiologies, and outcomes.
Because these patients generally participate in social life, risk factors associated
with lifestyle may have a great impact and need to be identified.
Methods
The SKY (Stroke in Korean Young Adults) study is a multicenter case–control study
and a prospective cohort study in 8 tertiary medical centers in the Republic of Korea.
The case subjects are patients aged 18-44 years with first-ever ischemic stroke occurring
within 1 month of stroke onset, and the control subjects are age- and gender-matched
community controls. Our aim is to include 470 cases and 470 controls. The main objective
of our study is to determine the risk factors and the causes of ischemic stroke in
Korean young adults. Both well-documented risk factors and little-known lifestyle-related
risk factors such as lifestyle habits and psychological distress including job strain
will be evaluated by comparing cases and controls using a structured questionnaire.
Secondary objectives are to determine the risks of mortality, recurrent vascular events,
and poststroke epilepsy in these patients. Conditional logistic regression analysis
will be used to estimate odds ratios and 95% confidence intervals.
Conclusions
The SKY study is designed to obtain more insights into relatively little-known risk
factors in young Korean adults with ischemic stroke. The results may also help identify
the frequencies of uncommon etiologies and outcomes in these patients.
Key Words
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Article info
Publication history
Published online: March 30, 2016
Accepted:
February 25,
2016
Received in revised form:
February 18,
2016
Received:
December 11,
2015
Footnotes
This work was supported by the research fund of the Cerebrovascular Research Club.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.02.034
Copyright
© 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
