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The authors report relevant funding from the University of Michigan Cancer Center Biostatistics Training Grant ( 5T32CA083654 ) and the National Institutes of Neurological Disorders and Stroke Clinical Trials Methodology Course ( R25 NS088248 ).
Author contributions: All authors made substantial contributions to the design, data acquisition, analysis, and interpretation of the data for this work. W.J.M. and K.K. drafted the manuscript, and N.J.S. revised it critically for important intellectual content. All approve of the final version and W.J.M. and KK take responsibility for the accuracy and integrity of the data presented.