Background
Metabolic syndrome (MetS) is recently proposed as a predictor for the occurrence of
vascular defects causing ischemic stroke. However, details on the association of MetS
with stroke are scare in our region. The present study aimed to assess the predictive
value of MetS and its components for stoke among the Iranian population.
Methods
A longitudinal population-based study was conducted on adults aged 35 years or older
who were living in 3 districts in central part of Iran and followed for 10 years.
Stroke was diagnosed using World Health Organization guidelines, and MetS was defined
according to the Adult Treatment Panel-III definition.
Results
Among the 5398 subjects, 2021 suffered from MetS with an incidence of 37.4%. The incidence
rates of stroke in those with and without MetS were 2.6% and 1.1%, respectively, with
a higher significance in the former group (P = .026). Compared to the controls, participants with stroke exhibited a higher prevalence
of some components of MetS including hyperglycemia and hypertension. On Cox proportional
hazard analysis, the hazard ratio for a long-term risk of ischemic stroke was 1.37
overall (95% confidence interval: 1.15-1.63, P < .001) in subjects with MetS. Considering different components of MetS, hyperglycemia
(hazard ratio = 1.83, P = .011) and hypertension (1.74, P = .019) could effectively predict occurrence of long-term ischemic stroke.
Conclusion
MetS and its main components can be potent predictors for long-term ischemic stroke.
Thus, the focus should be on identification and appropriate control of MetS components
to prevent stroke occurrence.
Key Words
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Article info
Publication history
Published online: October 18, 2016
Accepted:
September 13,
2016
Received in revised form:
August 20,
2016
Received:
June 6,
2016
Footnotes
Conflict of interest: None.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.019
Copyright
© 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.
