Background
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition characterized
by complex lesions of the lungs and other organs as well as a progressive obstruction
of the airway. In COPD patients, heart failure (HF) is associated with worse conditions
such as inflammation, arterial stiffness, and increased risk mortality. However, the
association of HF, COPD, and stroke are unclear; the examination of the role of HF,
especially right HF, about increased risk of stroke in COPD patients has not been
studied. We aimed to determine if right HF is a risk factor for stroke in patients
with COPD.
Materials and methods
A case-control study of patients with COPD was carried out. The cases were defined
as COPD patients with ischemic stroke and control COPD patients without stroke.
Results
A total of 162 patients with COPD were analyzed: COPD with stroke (n = 35) and COPD
alone (n = 127). COPD patients with right HF were at a greater risk of stroke compared
with patients without right HF (odds ratio 3.03, 95% confidence interval 1.13-10.12,
p = .044) adjusted for confounding factors.
Conclusions
Right HF is an independent risk factor for stroke, probably because of cerebrovascular
stasis secondary to congestion of the superior vena cava.
Key Words
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Article info
Publication history
Published online: August 22, 2017
Accepted:
July 25,
2017
Received in revised form:
July 24,
2017
Received:
June 1,
2017
Footnotes
All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Sources of funding: This work was supported by Consejo Nacional de Ciencia y Tecnología (CONACyT) [Studentship 262283].
Disclosures: None.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.07.027
Copyright
© 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.
