Abstract
Introduction: Elevated serum apolipoprotein B and the apolipoprotein B/A1 ratio have been associated
with ischemic stroke and intracranial atherosclerotic disease. We sought to assess
the relationship between serum levels of apolipoprotein B, apolipoprotein A1, and
the apolipoprotein B/A1 ratio with ischemic stroke subtypes and large artery atherosclerosis
location. Materials and Methods: We evaluated serum apolipoprotein B and apolipoprotein A1 levels in consecutive,
statin-naïve, adult ischemic stroke patients admitted to an academic medical center
in southern India. We evaluated for differences in the mean serum levels of apolipoprotein
B, apolipoprotein A1, and the apolipoprotein B/A1 ratio between patients with ischemic
stroke attributed to intracranial atherosclerotic disease, extracranial atherosclerotic
disease, small vessel disease, and cardioembolism. In secondary analysis, we assessed
for differences in these serum apolipoproteins between patients with moderate-severe
intracranial atherosclerotic disease and extracranial atherosclerotic disease, irrespective
of ischemic stroke subtype. Results: Among the 156 ischemic stroke patients enrolled in this study, there were no significant
differences in serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein
B/A1 ratio between patients with distinct ischemic stroke subtypes. No significant
differences were found in serum levels of apolipoprotein B, A1 and the apolipoprotein
B/A1 ratio between patients with moderate-severe intracranial atherosclerotic disease
and moderate-severe extracranial atherosclerotic disease. Discussion: Serum levels of apolipoprotein B and A1 did not differ between ischemic stroke subtypes.
Additional studies are needed to validate our findings and to better understand the
relationship between serum apolipoproteins and stroke.
Key Words
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Article info
Publication history
Published online: February 10, 2020
Accepted:
January 12,
2020
Received in revised form:
January 5,
2020
Received:
March 29,
2019
Footnotes
Grant Support: This project was supported by NIH Research Training Grant # R25 TW009337 funded by the Fogarty International Center.
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104670
Copyright
© 2020 Elsevier Inc. All rights reserved.
