Highlights
- •Among157 Chinese patients with intracerebral hemorrhage, 45 showed hematoma growth.
- •Study of a possible association of hematoma growth and indices of serum lipid.
- •No association detected between serum lipid indices and hematoma growth.
- •High baseline SBP correlated with an increased risk of hematoma growth.
Abstract
Objectives: Although several studies have shown that interventions to lower blood lipid concentration
may reduce the risk of coronary arterial disease and ischemic stroke, the correlation
between serum lipid levels and hemorrhagic stroke remains controversial. To clarify
any possible association between serum lipid and hematoma expansion, we examined various
serum lipid indices in patients with and without early hematoma expansion. Methods: Data of 572 intracerebral hemorrhage (ICH) patients from the cerebral small vessel
disease cohort of Peking Union Medical College Hospital were retrospectively analyzed.
Patients who finished the baseline brain computed tomography (CT) examination within
6 h post-ictus and the follow-up CT within 48 h after initial CT were included in
the study. Hematoma expansion was delimited as an enlargement of hemorrhage volume
over 33% or 12.5 mL between baseline and subsequent CT. Both uni- and multivariate
logistic regression analyses were conducted to explore the association between early
hematoma growth and various serum lipid indices, including triglycerides, total cholesterol
(TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol
(LDL-C), non-HDL-C, ratios of LDL-C/HDL-C and LDL-C/TC, as well as other demographic
and clinical features. Results: Out of 157 patients included in the analysis, hematoma growth occurred in 45 (28.7%).
Only higher baseline systolic blood pressure was found to be correlated with an increased
risk of hematoma growth based on both univariate (odds ratio [OR] 1.014, 95% confidence
interval [CI]: 1.002-1.026, P = .024) and multivariate logistic regression analyses (OR 1.022, 95%CI: 1.008-1.037,
P = .003). No associations were detected between the various serum lipid indices examined
and other clinical features with a likelihood of early hematoma growth between groups
or within various subgroups defined by different characteristics including age, gender,
baseline Glasgow Coma Scale score, systolic blood pressure, intraventricular extension,
and hematoma location. Conclusions: No association between various indices of serum lipid and hematoma growth was identified
among patients and subgroups with spontaneous ICH in the Chinese population; these
findings may help to guide lipid management after ICH. However, further multi-centered,
larger scale studies are expected to verify our results.
Key Words
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Article info
Publication history
Published online: March 27, 2020
Accepted:
February 26,
2020
Received in revised form:
February 22,
2020
Received:
January 4,
2020
Footnotes
Funding: This work was supported by the National Key Research and Development Program of China (2016 YFC0901004).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104793
Copyright
© 2020 Elsevier Inc. All rights reserved.
