Abstract
Background
Objective
Methods
Results
Conclusions
Key Words
Introduction
- Panigada M.
- Bottino N.
- Tagliabue P.
- Grasselli G.
- Novembrino C.
- Chantarangkul V.
- Tripodi A.
- Valderrama E.V.
- Humbert K.
- Lord A.
- Frontera J.
- Yaghi S.
Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Zhang S. (2020). Coagulopathy and antiphospholipid antibodies in patients with Covid-19. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161262/
Methods
Local case series and incidence
Methods of systematic review
Literature search strategy
Study and cohort selection
Data extraction
Risk of bias assessment
Statistical analyses
Results
Local case series and incidence



Systematic review results
- Cavalcanti DD
- Raz E
- Shapiro M
- Dehkharghani S
- Yaghi S
- Lillemoe K
- Nossek E
- Torres J
- Jain R
- Riina HA
- Radmanesh A
- Nelson PK
- Garaci F
- Di Giuliano F
- Picchi E
- Da Ros V
- Floris R
- Hemasian H
- Ansari B
- Hughes C
- Nichols T
- Pike M
- Subbe C
- Elghenzai S
- Klein D.E.
- Libman R.
- Kirsch C.
- Arora R.
- Li Y.
- Wang M.
- Zhou Y.
- Chang J.
- Xian Y.
- Mao L.
- Hu B.
- Malentacchi M
- Gned D
- Angelino V
- Demichelis S
- Perboni A
- Veltri A
- Bertolotto A
- Capobianco M
- Poillon G
- Obadia M
- Perrin M
- Savatovsky J
- Lecler A

Study | Patient | Country | Age (years) | Sex | Co-morbidities | COVID-19 symptoms | COVID-19 severity | Neurological symptoms | Days from COVID-19 symptoms | Location of CVT | ICH on Imaging | Prothrombotic work-up | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cavalcanti | 1 | US | 38 | M | Mild ASD | Diarrhea, vomiting Fever Headache | Critical | AMS | 10 | Cortical veins, R internal cerebral vein, straight sinus, distal superior sagittal sinus, torcular and R transverse sinus | Nil | EVT ACC | Death | |
2 | 41 | F | Nil | Mild | AMS Aphasia | Vein of Galen, internal cerebral veins, distal straight sinus | Yes | Raised D-dimer | EVD ACC | Death | ||||
3 | 23 | M | Nil | ARI, fever Headache Lethargy | Critical | GCS drop | 7 | Yes | Raised D-dimer, ferritin | Nil | Death | |||
Klein | 4 | 29 | F | Nil | ARI, dyspnea, fever Headache | Mild | Post-ictal AMS Aphasia Facial palsy Seizure | >7 | Distal L transverse and sigmoid sinus | Yes | Raised CRP, D-dimer, LDH, anti-CL IgM Low ferritin | ACC AED | Alive | |
Garaci | 5 | Italy | 44 | F | Nil | ARI, dyspnea, fever | Severe | AMS Aphasia Headache R hemiparesis | 14 | Vein of Galen, L internal cerebral vein, straight sinus | Nil | Raised D-dimer Normal anti-CL, anti-B2gp1, anti-dsDNA IgM | ACC | |
Malentacchi | 6 | 81 | M | Prostate CA CLL | Dyspnea | Critical | AMS GCS drop | R sigmoid sinus | Nil | Raised CRP, D-dimer, LDH Normal fibrinogen | ACC | Death | ||
Hughes | 7 | UK | 59 | M | Obesity HTN DM | Fever Headache | Moderate | Aphasia Dysarthria R hemiparesis R hypoesthesia | 4 | R transverse and sigmoid sinuses | Nil | Raised fibrinogen, CRP, ESR | ACC | Discharged |
Dahl-Cruz | 8 | Spain | 53 | M | Nil | Anosmia, dysgeusia ARI, dyspnea, fever Headache | Moderate | Ataxia R hemiparesis R hypoesthesia | 7 | Superior sagittal and R transverse sinus | Yes | Raised CRP, D-dimer | ACC AED | Discharged |
Poillon | 9 | France | 62 | F | Obesity | ARI, dyspnea, fever | Moderate | Blurry vision GCS drop Headache R hemiparesis | 15 | Vein of Galen, internal cerebral vein, straight sinus, L transverse sinus | Yes | Raised D-dimer | ||
10 | 54 | F | Breast CA | ARI, fever Lethargy | Moderate | Headache | 14 | L transverse sinus | Yes | Raised CRP, D-dimer Normal LDH | ||||
Hemasian | 11 | Iran | 65 | M | Nil | Nil | Mild | GCS drop Seizure | R transverse and sigmoid sinuses | Yes | Raised LDH Normal CRP, ESR | ACC AED | Discharged | |
Li | 12 | China | 32 | M | Smoking | Severe | 15 | ACC | Alive | |||||
Tu | 13 | SG | 30s | M | Nil | Fever | Mild | Headache | 1 | L transverse and sigmoid sinuses | Nil | Normal CRP, D-dimer, anti-CL IgM and IgG | ACC | Discharged |
14 | 30s | M | Nil | Nil | Mild | Seizure | 1 | L transverse and sigmoid sinuses, extending into the internal jugular vein. | Yes | Raised CRP, D-dimer, homocysteine, LAC, low protein C activity Normal protein S, anti-CL, anti-β2gp1 IgM and IgG | ACC AED | Death |
Discussion
Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Zhang S. (2020). Coagulopathy and antiphospholipid antibodies in patients with Covid-19. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161262/
- Mao L.
- Jin H.
- Wang M.
- Hu Y.
- Chen S.
- He Q.
- Hu B.
Connors JM, & Levy JH. (2020). Thromboinflammation and the hypercoagulability of COVID-19. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/32302453.
- Klein D.E.
- Libman R.
- Kirsch C.
- Arora R.
Tang N, Bai H, Chen X, Gong J, Li D, & Sun Z. (2020, April 27). Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Retrieved from: https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14817
- Middeldorp S.
- Coppens M.
- van Haaps T.F.
- Foppen M.
- Vlaar A.P.
- Müller M.
- Bouman C.
- Beenen L.
- Kootte R.S.
- Heijmans J.
- Smits L.P.
- Bonta P.I.
- van Es N.
Connors JM, & Levy JH. (2020). Thromboinflammation and the hypercoagulability of COVID-19. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/32302453.
Limitations
Conclusion
Declaration of Competing Interest
Funding
Availability of data and material
Patient consent for publication
Acknowledgements
Appendix. Supplementary materials
References
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Article info
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Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105379