COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation

      Novel coronavirus disease 2019 (COVID-19) has caused confirmed infections in more than 30 million Americans by April 2021, and 130 million worldwide, with a case fatality rate of up to 2-10% (https://ourworldindata.org/coronavirus/). It can cause ischemic and hemorrhagic strokes secondary to coagulopathy and endothelial injury.
      • Sashindranath M
      • Nandurkar HH.
      Endothelial dysfunction in the brain: setting the stage for stroke and other cerebrovascular complications of COVID-19.
      These same factors play a role in Cerebral Cavernous Malformation (CCM), an uncommon hemorrhagic neurovascular disease characterized by grossly dilated vascular “caverns” lined by a single layer of dysfunctional endothelium.
      • Awad IA
      • Polster SP.
      Cavernous angiomas: deconstructing a neurosurgical disease.
      We sought hypothesis-generating observations whether CCM patients contracting COVID-19 have a more severe illness, including a potentially higher risk of hemorrhagic events.

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