- •Recurrent infarcts on brain magnetic resonance imaging are common 6-8 weeks after index presentation in patients with symptomatic intracranial stenosis despite relatively high adherence to aggressive medical management.
- •Low-density lipoprotein and triglyceride levels at time of index stroke or transient ischemic attack predict recurrent infarcts independent of other clinical and imaging factors.
- •More aggressive and rapid reduction of lipid levels may be required to reduce the burden of early clinical and subclinical recurrence in patients with symptomatic intracranial stenosis.
Materials and Methods
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Grant Support: MYRIAD is supported through a grant by the NIH/NINDS (R01 NS084288). The institutional review board/ethics committee at each participating institution approved this study, which is registered at ClinicalTrials.gov (NCT02121028).